Abstract
Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 634-637 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 143 |
| Issue number | 3 |
| State | Published - 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Influence of geometry of transplanted tooth and bone on transformation of fibroblasts. / Reddi, A Hari; Huggins, C. B.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 143, No. 3, 1973, p. 634-637.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of geometry of transplanted tooth and bone on transformation of fibroblasts
AU - Reddi, A Hari
AU - Huggins, C. B.
PY - 1973
Y1 - 1973
N2 - Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.
AB - Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.
UR - http://www.scopus.com/inward/record.url?scp=0015839540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015839540&partnerID=8YFLogxK
M3 - Article
C2 - 4578252
AN - SCOPUS:0015839540
VL - 143
SP - 634
EP - 637
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 3
ER -