Influence of geometry of transplanted tooth and bone on transformation of fibroblasts

A Hari Reddi, C. B. Huggins

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.

Original languageEnglish (US)
Pages (from-to)634-637
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume143
Issue number3
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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