Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - 1973|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)