Influence of geometry of transplanted tooth and bone on transformation of fibroblasts

A Hari Reddi; C. B. Huggins

Influence of geometry of transplanted tooth and bone on transformation of fibroblasts

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Abstract

Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, ³⁵S and ³²P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.

Original language	English (US)
Pages (from-to)	634-637
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	143
Issue number	3
State	Published - 1973
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.",

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year = "1973",

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AB - Allogeneic transplants of demineralized powdered bone or whole teeth in different shapes transformed fibroblasts to cartilage and bone. Coarse powders of bone elicited significantly higher yields of transfomation products than fine powder did; criteria of transformation included histologic findings, alkaline phosphatase activity, 35S and 32P incorporation. The temporal sequence of fibroblast chondroblast osteoblast transformation was profoundly influenced by the geometry of the transformant. The incursion of capillaries among the transformed cells resulted in chondrolysis.

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