Influence of feeding unsaturated fats on growth and immune status of mice

A. Berger, J. B. German, B. L. Chiang, A. A. Ansari, Carl L Keen, M. P. Fletcher, M. Eric Gershwin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Dietary polyunsaturated fatty acids alter the lipid composition and immune systems of mice. To date, most studies have been of short duration and focused on a particular immunologic assay. Adult female mice were therefore fed diets rich in 18:1(n-9) (olive oil), 18:2(n-6) (safflower oil), 18:3(n- 3) (linseed oil) or 20:5(n-3) and 22:6(n-3) (fish oil-safflower oil, 9:1, wt/wt), for a 5-mo period, encompassing two breeding cycles. Offspring from the second breeding cycle were then fed these diets for 42 d, and a spectrum of immune functions was assessed. Dietary fat had a small effect on gestational weight gain and total and relative organ weights of the offspring. The relative amounts of splenic Ly-2 and γδ receptor-expressing T cells were proportional to the concentration of 18:2(n-6), and inversely proportional to the concentration of long chain (n-3) polyenes in the diet. In contrast, Ly-1, immunoglobulin M, GM1+, and Ly-1 B suppressor inducer cells were not significantly affected by dietary fat. Splenic natural killer cell and lymphokine activated killer cell activities were attenuated by (n- 3) polyunsaturated fatty acids, in contrast to superoxide production of stimulated macrophages which was increased. Those immune functions that were sensitive to dietary fat modulation will be the focus of continued research.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalJournal of Nutrition
Volume123
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Unsaturated Fats
Dietary Fats
dietary fat
Safflower Oil
safflower oil
Diet
Breeding
polyunsaturated fatty acids
mice
Growth
diet
Linseed Oil
lymphokines
Polyenes
Lymphokine-Activated Killer Cells
immunoglobulin M
Organ Size
Fish Oils
linseed oil
breeding

Keywords

  • fatty acids
  • fish oil
  • growth rate
  • immune system
  • mice

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Berger, A., German, J. B., Chiang, B. L., Ansari, A. A., Keen, C. L., Fletcher, M. P., & Gershwin, M. E. (1993). Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition, 123(2), 225-233.

Influence of feeding unsaturated fats on growth and immune status of mice. / Berger, A.; German, J. B.; Chiang, B. L.; Ansari, A. A.; Keen, Carl L; Fletcher, M. P.; Gershwin, M. Eric.

In: Journal of Nutrition, Vol. 123, No. 2, 1993, p. 225-233.

Research output: Contribution to journalArticle

Berger, A, German, JB, Chiang, BL, Ansari, AA, Keen, CL, Fletcher, MP & Gershwin, ME 1993, 'Influence of feeding unsaturated fats on growth and immune status of mice', Journal of Nutrition, vol. 123, no. 2, pp. 225-233.
Berger A, German JB, Chiang BL, Ansari AA, Keen CL, Fletcher MP et al. Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition. 1993;123(2):225-233.
Berger, A. ; German, J. B. ; Chiang, B. L. ; Ansari, A. A. ; Keen, Carl L ; Fletcher, M. P. ; Gershwin, M. Eric. / Influence of feeding unsaturated fats on growth and immune status of mice. In: Journal of Nutrition. 1993 ; Vol. 123, No. 2. pp. 225-233.
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