Abstract
Dietary polyunsaturated fatty acids alter the lipid composition and immune systems of mice. To date, most studies have been of short duration and focused on a particular immunologic assay. Adult female mice were therefore fed diets rich in 18:1(n-9) (olive oil), 18:2(n-6) (safflower oil), 18:3(n- 3) (linseed oil) or 20:5(n-3) and 22:6(n-3) (fish oil-safflower oil, 9:1, wt/wt), for a 5-mo period, encompassing two breeding cycles. Offspring from the second breeding cycle were then fed these diets for 42 d, and a spectrum of immune functions was assessed. Dietary fat had a small effect on gestational weight gain and total and relative organ weights of the offspring. The relative amounts of splenic Ly-2 and γδ receptor-expressing T cells were proportional to the concentration of 18:2(n-6), and inversely proportional to the concentration of long chain (n-3) polyenes in the diet. In contrast, Ly-1, immunoglobulin M, GM1+, and Ly-1 B suppressor inducer cells were not significantly affected by dietary fat. Splenic natural killer cell and lymphokine activated killer cell activities were attenuated by (n- 3) polyunsaturated fatty acids, in contrast to superoxide production of stimulated macrophages which was increased. Those immune functions that were sensitive to dietary fat modulation will be the focus of continued research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-233 |
| Number of pages | 9 |
| Journal | Journal of Nutrition |
| Volume | 123 |
| Issue number | 2 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- fatty acids
- fish oil
- growth rate
- immune system
- mice
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
Cite this
Influence of feeding unsaturated fats on growth and immune status of mice. / Berger, A.; German, J. B.; Chiang, B. L.; Ansari, A. A.; Keen, Carl L; Fletcher, M. P.; Gershwin, M. Eric.
In: Journal of Nutrition, Vol. 123, No. 2, 1993, p. 225-233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of feeding unsaturated fats on growth and immune status of mice
AU - Berger, A.
AU - German, J. B.
AU - Chiang, B. L.
AU - Ansari, A. A.
AU - Keen, Carl L
AU - Fletcher, M. P.
AU - Gershwin, M. Eric
PY - 1993
Y1 - 1993
N2 - Dietary polyunsaturated fatty acids alter the lipid composition and immune systems of mice. To date, most studies have been of short duration and focused on a particular immunologic assay. Adult female mice were therefore fed diets rich in 18:1(n-9) (olive oil), 18:2(n-6) (safflower oil), 18:3(n- 3) (linseed oil) or 20:5(n-3) and 22:6(n-3) (fish oil-safflower oil, 9:1, wt/wt), for a 5-mo period, encompassing two breeding cycles. Offspring from the second breeding cycle were then fed these diets for 42 d, and a spectrum of immune functions was assessed. Dietary fat had a small effect on gestational weight gain and total and relative organ weights of the offspring. The relative amounts of splenic Ly-2 and γδ receptor-expressing T cells were proportional to the concentration of 18:2(n-6), and inversely proportional to the concentration of long chain (n-3) polyenes in the diet. In contrast, Ly-1, immunoglobulin M, GM1+, and Ly-1 B suppressor inducer cells were not significantly affected by dietary fat. Splenic natural killer cell and lymphokine activated killer cell activities were attenuated by (n- 3) polyunsaturated fatty acids, in contrast to superoxide production of stimulated macrophages which was increased. Those immune functions that were sensitive to dietary fat modulation will be the focus of continued research.
AB - Dietary polyunsaturated fatty acids alter the lipid composition and immune systems of mice. To date, most studies have been of short duration and focused on a particular immunologic assay. Adult female mice were therefore fed diets rich in 18:1(n-9) (olive oil), 18:2(n-6) (safflower oil), 18:3(n- 3) (linseed oil) or 20:5(n-3) and 22:6(n-3) (fish oil-safflower oil, 9:1, wt/wt), for a 5-mo period, encompassing two breeding cycles. Offspring from the second breeding cycle were then fed these diets for 42 d, and a spectrum of immune functions was assessed. Dietary fat had a small effect on gestational weight gain and total and relative organ weights of the offspring. The relative amounts of splenic Ly-2 and γδ receptor-expressing T cells were proportional to the concentration of 18:2(n-6), and inversely proportional to the concentration of long chain (n-3) polyenes in the diet. In contrast, Ly-1, immunoglobulin M, GM1+, and Ly-1 B suppressor inducer cells were not significantly affected by dietary fat. Splenic natural killer cell and lymphokine activated killer cell activities were attenuated by (n- 3) polyunsaturated fatty acids, in contrast to superoxide production of stimulated macrophages which was increased. Those immune functions that were sensitive to dietary fat modulation will be the focus of continued research.
KW - fatty acids
KW - fish oil
KW - growth rate
KW - immune system
KW - mice
UR - http://www.scopus.com/inward/record.url?scp=0027419465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027419465&partnerID=8YFLogxK
M3 - Article
C2 - 8381477
AN - SCOPUS:0027419465
VL - 123
SP - 225
EP - 233
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 2
ER -