Influence of dietary manganese and vitamin e on adriamycin toxicity in mice

Sheri Zidenberg-Cherr, Carl L Keen

Research output: Contribution to journalArticle

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Abstract

Adriamycin (ADR) administration can result in cardiac toxicity. One suggested mechanism of damage is through increased lipid peroxidation. We have evaluated the biochemical response of mice to ADR treatment when fed Mn-sufficient, vitamin E-sufficient (+Mn, +E); Mn-sufficient, low vitamin-E (+Mn, -E); Mn-deficient, vitamin E-sufficient (-Mn, +E); or Mn-deficient, low vitamin-E (-Mn, -E) diets. Mice were injected i.p. with ADR (10 mg kg bw) or saline (0.9% w/v). ADR injection resulted in a reduction of food intake by 2 days postinjection; by 5 days postinjection ADR-treated mice lost an average of 6.0 g. Heart Mn Superoxide dismutase (SOD) activity of -Mn mice was 50% that of + Mn mice; ADR did not affect MnSOD activity. Lipid peroxidation was highest in the -Mn, -E mice, being 2-fold higher than that observed in + Mn, + E mice. ADR injection did not affect lipid peroxidation. An interaction between Fe and ADR treatment was apparent; ADR injected -Mn, -E mice had liver Fe concentrations which were twice that of the saline injected mice fed -Mn, -E diets. These data show that the antioxidant status of an animal may influence ADR toxicity.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalToxicology Letters
Volume30
Issue number1
DOIs
StatePublished - 1986

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Manganese
Vitamins
Doxorubicin
Toxicity
Vitamin E
Lipid Peroxidation
Nutrition
Lipids
Diet
Injections
Tocopherols
Liver
Superoxide Dismutase
Animals
Eating
Antioxidants
Therapeutics

ASJC Scopus subject areas

  • Toxicology

Cite this

Influence of dietary manganese and vitamin e on adriamycin toxicity in mice. / Zidenberg-Cherr, Sheri; Keen, Carl L.

In: Toxicology Letters, Vol. 30, No. 1, 1986, p. 79-87.

Research output: Contribution to journalArticle

Zidenberg-Cherr, Sheri ; Keen, Carl L. / Influence of dietary manganese and vitamin e on adriamycin toxicity in mice. In: Toxicology Letters. 1986 ; Vol. 30, No. 1. pp. 79-87.
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