Influence of dietary-induced copper and manganese deficiency on ozone-induced changes in lung and liver antioxidant systems

Sheri Zidenberg-Cherr, Bin Han, Michael A. Dubick, Carl L Keen

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.

Original languageEnglish (US)
Pages (from-to)81-90
Number of pages10
JournalToxicology Letters
Volume57
Issue number1
DOIs
StatePublished - 1991

Keywords

  • Copper
  • Glutathione
  • Manganese
  • Olutathione peroxidase
  • Ozone
  • Superoxide dismutase

ASJC Scopus subject areas

  • Toxicology

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