Abstract
The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-90 |
| Number of pages | 10 |
| Journal | Toxicology Letters |
| Volume | 57 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1991 |
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Keywords
- Copper
- Glutathione
- Manganese
- Olutathione peroxidase
- Ozone
- Superoxide dismutase
ASJC Scopus subject areas
- Toxicology
Cite this
Influence of dietary-induced copper and manganese deficiency on ozone-induced changes in lung and liver antioxidant systems. / Zidenberg-Cherr, Sheri; Han, Bin; Dubick, Michael A.; Keen, Carl L.
In: Toxicology Letters, Vol. 57, No. 1, 1991, p. 81-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of dietary-induced copper and manganese deficiency on ozone-induced changes in lung and liver antioxidant systems
AU - Zidenberg-Cherr, Sheri
AU - Han, Bin
AU - Dubick, Michael A.
AU - Keen, Carl L
PY - 1991
Y1 - 1991
N2 - The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.
AB - The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.
KW - Copper
KW - Glutathione
KW - Manganese
KW - Olutathione peroxidase
KW - Ozone
KW - Superoxide dismutase
UR - http://www.scopus.com/inward/record.url?scp=0025732667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025732667&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(91)90122-M
DO - 10.1016/0378-4274(91)90122-M
M3 - Article
C2 - 2048164
AN - SCOPUS:0025732667
VL - 57
SP - 81
EP - 90
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 1
ER -