Abstract
The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.
Original language | English (US) |
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Pages (from-to) | 81-90 |
Number of pages | 10 |
Journal | Toxicology Letters |
Volume | 57 |
Issue number | 1 |
DOIs | |
State | Published - 1991 |
Keywords
- Copper
- Glutathione
- Manganese
- Olutathione peroxidase
- Ozone
- Superoxide dismutase
ASJC Scopus subject areas
- Toxicology