Abstract
The effect of dietary fat concentration and saturation on cell composition and structure of line 168 mouse mammary tumors in vivo was studied using morphometry and electron microscopy. Both the concentration and saturation of fat fed to mice had a significant influence on the volume ratio of mast cells infiltrating line 168 tumors. Tumors of mice fed diets containing a high concentration (20%) of either safflower oil (SO) or palm oil (PO) had 2-3 times the volume ratio of mast cells than mice fed diets containing a low concentration (5%) of either fat. There were no significant differences among diets with respect to other inflammatory cell populations. Mice fed either one of the high fat diets had tumor cells with inclusions that ultrastructurally, appeared to consist of lipid. Dietary fat, however, had no observable affect on cell junctions or other morphological characteristics. Greater infiltration of mast cells in tumors of mice fed high fat diets and the eventual formation of new blood capillaries may explain the decreased latency of tumor onset and enhanced growth of tumors in mice fed diets with high concentrations of fat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-294 |
| Number of pages | 14 |
| Journal | Cancer Letters |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1987 |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Influence of dietary fats on cell populations of line 168 mouse mammary tumors : A morphometric and ultrastructural study. / Hubbard, Neil; Erickson, Kent L.
In: Cancer Letters, Vol. 35, No. 3, 1987, p. 281-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of dietary fats on cell populations of line 168 mouse mammary tumors
T2 - A morphometric and ultrastructural study
AU - Hubbard, Neil
AU - Erickson, Kent L
PY - 1987
Y1 - 1987
N2 - The effect of dietary fat concentration and saturation on cell composition and structure of line 168 mouse mammary tumors in vivo was studied using morphometry and electron microscopy. Both the concentration and saturation of fat fed to mice had a significant influence on the volume ratio of mast cells infiltrating line 168 tumors. Tumors of mice fed diets containing a high concentration (20%) of either safflower oil (SO) or palm oil (PO) had 2-3 times the volume ratio of mast cells than mice fed diets containing a low concentration (5%) of either fat. There were no significant differences among diets with respect to other inflammatory cell populations. Mice fed either one of the high fat diets had tumor cells with inclusions that ultrastructurally, appeared to consist of lipid. Dietary fat, however, had no observable affect on cell junctions or other morphological characteristics. Greater infiltration of mast cells in tumors of mice fed high fat diets and the eventual formation of new blood capillaries may explain the decreased latency of tumor onset and enhanced growth of tumors in mice fed diets with high concentrations of fat.
AB - The effect of dietary fat concentration and saturation on cell composition and structure of line 168 mouse mammary tumors in vivo was studied using morphometry and electron microscopy. Both the concentration and saturation of fat fed to mice had a significant influence on the volume ratio of mast cells infiltrating line 168 tumors. Tumors of mice fed diets containing a high concentration (20%) of either safflower oil (SO) or palm oil (PO) had 2-3 times the volume ratio of mast cells than mice fed diets containing a low concentration (5%) of either fat. There were no significant differences among diets with respect to other inflammatory cell populations. Mice fed either one of the high fat diets had tumor cells with inclusions that ultrastructurally, appeared to consist of lipid. Dietary fat, however, had no observable affect on cell junctions or other morphological characteristics. Greater infiltration of mast cells in tumors of mice fed high fat diets and the eventual formation of new blood capillaries may explain the decreased latency of tumor onset and enhanced growth of tumors in mice fed diets with high concentrations of fat.
UR - http://www.scopus.com/inward/record.url?scp=0023353325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023353325&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(87)90130-3
DO - 10.1016/0304-3835(87)90130-3
M3 - Article
C2 - 3036343
AN - SCOPUS:0023353325
VL - 35
SP - 281
EP - 294
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 3
ER -