Influence of dietary carbohydrate on the expression of zinc deficiency in the rats

S. H. Kim, B. Han, Carl L Keen

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It has been reported that signs of Cu deficiency develop more rapidly in fructose-fed rats than in glucose-fed animals. In the present study we investigated the influence of dietary carbohydrate type on the expression of Zn deficiency induced oxidative damage in the rats. Male rats (50±2g) were fed for 17 days ad libitum diets containing 25 ug Zn/g diet (control; +Zn) or 0.5 ug Zn/g diet (deficient; -Zn) and either 59.5% glucose or fructose. Restricted fed control groups for each of the -Zn groups were also studied. Plasma and liver Zn concentrations were lower in the -Zn rats than in controls; carbohydrate type had no influence on these parameters. Liver GSH and GSSG concentrations were higher in the Zn- rats than in the +Zn rats; this effect was most pronounced in the fructose group. Liver glutalhione peroxidase and glutathione reductase activities were higher in fructose-fed rats than in glucose-fed animals: the increase was reduced in Zn rats. Liver TBARS productions were similar in the six groups. These results suggest that while fructose feeding was associated with an increase in oxidative pressure, this did not result in evidence of increased oxidative damage in either +Zn or -Zn rats.

Original languageEnglish (US)
JournalFASEB Journal
Issue number3
StatePublished - 1997

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology


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