Influence of dietary aluminum on cytokine production by mitogen-stimulated spleen cells from swiss webster mice

M. S. Golub, P. T. Takeuchi, M. Eric Gershwin, S. H. Yoshida

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Swiss Webster mice were exposed to excess dietary aluminum (Al) (1000 μg Al/g diet, Al as Al lactate) from conception to 6 months of age. Splenic lymphocytes (106 per culture) were incubated for 24 hrs with concanavalin A (5 μg/ml). Concentrations of interleukin-2, interferon-γ and tumor necrosis factor-a, as measured in supernatants via ELISA with monoclonal antibodies, were depressed in spleen cells from aluminum treated mice relative to controls. Experiments using the flourescence activated cell sorter demonstrated a shift in T-cell populations from treated mice with a deficiency of CD4+ cells. These findings suggest a deficit in immune effector cell function after long term in vivo aluminum exposure.

Original languageEnglish (US)
Pages (from-to)605-619
Number of pages15
JournalImmunopharmacology and Immunotoxicology
Volume15
Issue number5
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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