Influence of cross-correlation between dipolar and chemical shift anisotropy relaxation mechanisms upon the transverse relaxation rates of 15N in macromolecules

Jonathan Boyd, Ulrich Hommel, Viswanathan V Krishnan

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Heteronuclear multiple-quantum coherence relaxation rate are calculated for the individual transitions of the S spin in an AIS nuclear spin system assuming that the heteronucleus (S spin) has relaxation contributions from both intramolecular dipole-dipole and chemical shift anisotropy relaxation. The individual multiplet components of the heteronuclear zero- and double-quantum coherences are shown to have different transverse relaxation rates. The cross-correlation between the two relaxation mechanisms is shown to be the dominant cause of the calculated differential line broadening. Experimental data are presented using as an example a uniformly 15N labelled sample of human epidermal growth factor.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalChemical Physics Letters
Volume187
Issue number3
DOIs
StatePublished - Dec 6 1991
Externally publishedYes

Fingerprint

Chemical shift
Macromolecules
macromolecules
cross correlation
chemical equilibrium
Anisotropy
anisotropy
shift
Epidermal Growth Factor
dipoles
nuclear spin
fine structure
causes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics
  • Surfaces and Interfaces

Cite this

@article{daa5f21001824bbdab58b5aa5aea4c93,
title = "Influence of cross-correlation between dipolar and chemical shift anisotropy relaxation mechanisms upon the transverse relaxation rates of 15N in macromolecules",
abstract = "Heteronuclear multiple-quantum coherence relaxation rate are calculated for the individual transitions of the S spin in an AIS nuclear spin system assuming that the heteronucleus (S spin) has relaxation contributions from both intramolecular dipole-dipole and chemical shift anisotropy relaxation. The individual multiplet components of the heteronuclear zero- and double-quantum coherences are shown to have different transverse relaxation rates. The cross-correlation between the two relaxation mechanisms is shown to be the dominant cause of the calculated differential line broadening. Experimental data are presented using as an example a uniformly 15N labelled sample of human epidermal growth factor.",
author = "Jonathan Boyd and Ulrich Hommel and Krishnan, {Viswanathan V}",
year = "1991",
month = "12",
day = "6",
doi = "10.1016/0009-2614(91)90432-9",
language = "English (US)",
volume = "187",
pages = "317--324",
journal = "Chemical Physics Letters",
issn = "0009-2614",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Influence of cross-correlation between dipolar and chemical shift anisotropy relaxation mechanisms upon the transverse relaxation rates of 15N in macromolecules

AU - Boyd, Jonathan

AU - Hommel, Ulrich

AU - Krishnan, Viswanathan V

PY - 1991/12/6

Y1 - 1991/12/6

N2 - Heteronuclear multiple-quantum coherence relaxation rate are calculated for the individual transitions of the S spin in an AIS nuclear spin system assuming that the heteronucleus (S spin) has relaxation contributions from both intramolecular dipole-dipole and chemical shift anisotropy relaxation. The individual multiplet components of the heteronuclear zero- and double-quantum coherences are shown to have different transverse relaxation rates. The cross-correlation between the two relaxation mechanisms is shown to be the dominant cause of the calculated differential line broadening. Experimental data are presented using as an example a uniformly 15N labelled sample of human epidermal growth factor.

AB - Heteronuclear multiple-quantum coherence relaxation rate are calculated for the individual transitions of the S spin in an AIS nuclear spin system assuming that the heteronucleus (S spin) has relaxation contributions from both intramolecular dipole-dipole and chemical shift anisotropy relaxation. The individual multiplet components of the heteronuclear zero- and double-quantum coherences are shown to have different transverse relaxation rates. The cross-correlation between the two relaxation mechanisms is shown to be the dominant cause of the calculated differential line broadening. Experimental data are presented using as an example a uniformly 15N labelled sample of human epidermal growth factor.

UR - http://www.scopus.com/inward/record.url?scp=0001365263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001365263&partnerID=8YFLogxK

U2 - 10.1016/0009-2614(91)90432-9

DO - 10.1016/0009-2614(91)90432-9

M3 - Article

AN - SCOPUS:0001365263

VL - 187

SP - 317

EP - 324

JO - Chemical Physics Letters

JF - Chemical Physics Letters

SN - 0009-2614

IS - 3

ER -