Influence of aluminum on mineralization during matrix-induced bone development

H. S. Talwar, A Hari Reddi, J. Menczel, W. C. Thomas, J. L. Meyer

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


A model of de novo mineralization employing matrix-induced endochondral bone formation in rats was used to study the short-term effects of aluminum on the deposition of calcium and phosphate in vivo. In experiments where systemic aluminum concentrations were elevated, the cellular processes associated with bone development appeared to be normal, if somewhat delayed, however precipitation of the mineral phase was prevented. This suggests a primary direct physical chemical effect of aluminum in vivo on calcification, as suggested by in vitro studies which demonstrate that aluminum is a potent inhibitor of calcium phosphate precipitation. Aluminum salts implanted locally with the matrix appeared to be toxic to the cellular processes leading to chondrogenesis and osteogenesis.

Original languageEnglish (US)
Pages (from-to)1038-1042
Number of pages5
JournalKidney International
Issue number5
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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