Abstract
A model of de novo mineralization employing matrix-induced endochondral bone formation in rats was used to study the short-term effects of aluminum on the deposition of calcium and phosphate in vivo. In experiments where systemic aluminum concentrations were elevated, the cellular processes associated with bone development appeared to be normal, if somewhat delayed, however precipitation of the mineral phase was prevented. This suggests a primary direct physical chemical effect of aluminum in vivo on calcification, as suggested by in vitro studies which demonstrate that aluminum is a potent inhibitor of calcium phosphate precipitation. Aluminum salts implanted locally with the matrix appeared to be toxic to the cellular processes leading to chondrogenesis and osteogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1038-1042 |
| Number of pages | 5 |
| Journal | Kidney International |
| Volume | 29 |
| Issue number | 5 |
| State | Published - 1986 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Nephrology
Cite this
Influence of aluminum on mineralization during matrix-induced bone development. / Talwar, H. S.; Reddi, A Hari; Menczel, J.; Thomas, W. C.; Meyer, J. L.
In: Kidney International, Vol. 29, No. 5, 1986, p. 1038-1042.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of aluminum on mineralization during matrix-induced bone development
AU - Talwar, H. S.
AU - Reddi, A Hari
AU - Menczel, J.
AU - Thomas, W. C.
AU - Meyer, J. L.
PY - 1986
Y1 - 1986
N2 - A model of de novo mineralization employing matrix-induced endochondral bone formation in rats was used to study the short-term effects of aluminum on the deposition of calcium and phosphate in vivo. In experiments where systemic aluminum concentrations were elevated, the cellular processes associated with bone development appeared to be normal, if somewhat delayed, however precipitation of the mineral phase was prevented. This suggests a primary direct physical chemical effect of aluminum in vivo on calcification, as suggested by in vitro studies which demonstrate that aluminum is a potent inhibitor of calcium phosphate precipitation. Aluminum salts implanted locally with the matrix appeared to be toxic to the cellular processes leading to chondrogenesis and osteogenesis.
AB - A model of de novo mineralization employing matrix-induced endochondral bone formation in rats was used to study the short-term effects of aluminum on the deposition of calcium and phosphate in vivo. In experiments where systemic aluminum concentrations were elevated, the cellular processes associated with bone development appeared to be normal, if somewhat delayed, however precipitation of the mineral phase was prevented. This suggests a primary direct physical chemical effect of aluminum in vivo on calcification, as suggested by in vitro studies which demonstrate that aluminum is a potent inhibitor of calcium phosphate precipitation. Aluminum salts implanted locally with the matrix appeared to be toxic to the cellular processes leading to chondrogenesis and osteogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0022599557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022599557&partnerID=8YFLogxK
M3 - Article
C2 - 3723926
AN - SCOPUS:0022599557
VL - 29
SP - 1038
EP - 1042
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 5
ER -