Influence of alcohol on folate status and methionine metabolism in relation to alcoholic liver disease

Charles H. Halsted, Valentina Medici, Farah Esfandiari

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Alcoholic beverages are consumed to some extent by about two-thirds of the US population over age 14. Alcohol abuse, defi ned roughly as chronic usage affecting patterns of daily living including health, legal, or societal problems, is found in about 5% of the US population, with greater prevalence in men (7%) than in women (2.5%) and in those aged 18 to 44 years [1]. Alcoholic liver disease (ALD), the principal medical complication of chronic alcoholism, occurs in about 20% of persons with chronic alcoholism, has an overall mortality of 9.6 in 100,000, and is the 12th leading cause of death in the United States [2]. The risk of ALD is dependent on a daily intake of more than 30 g of alcohol, as found in two shots of 80-proof liquor, two glasses of wine, or two cans of beer, for at least 10 years [2]. In addition, ALD patients typically exhibit multiple vitamin defi ciencies, most commonly those of folate, thiamin, and vitamin B6 [3]. As discussed in this chapter, folate defi ciency is prevalent among persons with chronic alcoholism and, through its effects on aberrant methionine metabolism in the liver, may play a central role in the pathogenesis of ALD.

Original languageEnglish (US)
Title of host publicationFolate in Health and Disease, Second Edition
PublisherCRC Press
Number of pages20
ISBN (Electronic)9781420071252
ISBN (Print)9781420071245
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Medicine(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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