Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia

Rita M. Ryan, Qadeer Ahmed, Satyanarayana Lakshminrusimha

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

Inflammation is important in the development of bronchopulmonary dysplasia (BPD). Polymorphonuclear cells and macrophages and proinflammatory cytokines/chemokines denote early inflammation in clinical scenarios such as in utero inflammation with chorioamnionitis or initial lung injury associated with respiratory distress syndrome or ventilator-induced lung injury. The persistence and non-resolution of lung inflammation contributes greatly to BPD, including altering the lung's ability to repair, contributing to fibrosis, and inhibiting secondary septation, alveolarization, and normal vascular development. Further understanding of the role of inflammation in the pathogenesis of BPD, in particular, during the chronic inflammatory period, offers us the opportunity to develop inflammation-related prevention and treatment strategies of this disease that has long-standing consequences for very premature infants.

Original languageEnglish (US)
Pages (from-to)174-190
Number of pages17
JournalClinical Reviews in Allergy and Immunology
Volume34
Issue number2
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Bronchopulmonary Dysplasia
Inflammation
Ventilator-Induced Lung Injury
Chorioamnionitis
Lung Injury
Chemokines
Premature Infants
Blood Vessels
Pneumonia
Fibrosis
Macrophages
Cytokines
Lung

Keywords

  • Bronchopulmonary dysplasia
  • Inflammatory mediators
  • Premature infants

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. / Ryan, Rita M.; Ahmed, Qadeer; Lakshminrusimha, Satyanarayana.

In: Clinical Reviews in Allergy and Immunology, Vol. 34, No. 2, 01.04.2008, p. 174-190.

Research output: Contribution to journalReview article

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