Inflammation in bone physiology and pathology

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Purpose of review Bone is constantly being remodeled throughout adult life through constant anabolic and catabolic actions that maintain tissue homeostasis. A number of hormones, cytokines growth factors, and the proximity of various cells to bone surfaces influence this process. Inflammatory changes at the bone microenvironment result in alterations leading to both excessive bone loss and bone formation. Detailed understanding of the physiological and pathological mechanisms that dictate these changes will allow us to harness inflammatory signals in bone regeneration. Recent findings Recent reports have suggested that inflammatory signals are able to stimulate transcription factors that regulate osteoblast differentiation from their precursors. Summary In this review, we summarized current understanding of the roles of inflammation in bone resorption and bone formation, which give rise to different disorders and discuss the huge potential of harnessing these inflammatory signals to achieve bone regeneration.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalCurrent Opinion in Rheumatology
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2018

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Keywords

  • bone loss
  • inflammation
  • osteoblasts bone formation
  • osteoclasts

ASJC Scopus subject areas

  • Rheumatology

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