Abstract
Increasing evidence supports an important role for inflammation in all phases of atherosclerosis, from initiation of the fatty streak to final culmination in acute coronary syndromes. Numerous inflammatory biomarkers including cell adhesion molecules, cytokines, chemokines, and acute-phase reactants such as fibrinogen, serum amyloid A, and C-reactive protein (CRP) have been shown to predict cardiovascular (CVD) events. Several prospective studies have shown a consistent and robust relationship between levels of high-sensitivity CRP and the risk of future CVD events. Toll-like receptors are pattern recognition receptors and members of the innate immune system that contribute to inflammation and appear to play key roles in atherosclerosis. Lipoprotein-associated phospholipase A2 may also be an independent CVD risk factor. Psoriasis has been associated with an increasing risk for atherosclerosis, including coronary artery disease and stroke. Patients with psoriasis have a 5-year shorter life expectancy, most frequently due to CVD. Psoriasis is associated with a chronic inflammatory state and with elevated levels of CRP and other inflammatory cytokines and these may play a causative role in the increased risk of psoriatic patients for CVD. Patients with psoriasis may represent an emerging risk population and patients with moderate to severe psoriasis should be screened and aggressively treated for CVD risk factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 194-204 |
| Number of pages | 11 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 44 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- C-reactive protein
- Coronary artery disease
- Inflammatory biomarkers
- Lipoprotein-associated phospholipase A
- Psoriasis
- Toll-like receptors
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Inflammation, atherosclerosis, and psoriasis. / Siegel, David; Devaraj, Sridevi; Mitra, Anupam; Raychaudhuri, Siba P; Raychaudhuri, Smriti K.; Jialal, Ishwarlal.
In: Clinical Reviews in Allergy and Immunology, Vol. 44, No. 2, 2013, p. 194-204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammation, atherosclerosis, and psoriasis
AU - Siegel, David
AU - Devaraj, Sridevi
AU - Mitra, Anupam
AU - Raychaudhuri, Siba P
AU - Raychaudhuri, Smriti K.
AU - Jialal, Ishwarlal
PY - 2013
Y1 - 2013
N2 - Increasing evidence supports an important role for inflammation in all phases of atherosclerosis, from initiation of the fatty streak to final culmination in acute coronary syndromes. Numerous inflammatory biomarkers including cell adhesion molecules, cytokines, chemokines, and acute-phase reactants such as fibrinogen, serum amyloid A, and C-reactive protein (CRP) have been shown to predict cardiovascular (CVD) events. Several prospective studies have shown a consistent and robust relationship between levels of high-sensitivity CRP and the risk of future CVD events. Toll-like receptors are pattern recognition receptors and members of the innate immune system that contribute to inflammation and appear to play key roles in atherosclerosis. Lipoprotein-associated phospholipase A2 may also be an independent CVD risk factor. Psoriasis has been associated with an increasing risk for atherosclerosis, including coronary artery disease and stroke. Patients with psoriasis have a 5-year shorter life expectancy, most frequently due to CVD. Psoriasis is associated with a chronic inflammatory state and with elevated levels of CRP and other inflammatory cytokines and these may play a causative role in the increased risk of psoriatic patients for CVD. Patients with psoriasis may represent an emerging risk population and patients with moderate to severe psoriasis should be screened and aggressively treated for CVD risk factors.
AB - Increasing evidence supports an important role for inflammation in all phases of atherosclerosis, from initiation of the fatty streak to final culmination in acute coronary syndromes. Numerous inflammatory biomarkers including cell adhesion molecules, cytokines, chemokines, and acute-phase reactants such as fibrinogen, serum amyloid A, and C-reactive protein (CRP) have been shown to predict cardiovascular (CVD) events. Several prospective studies have shown a consistent and robust relationship between levels of high-sensitivity CRP and the risk of future CVD events. Toll-like receptors are pattern recognition receptors and members of the innate immune system that contribute to inflammation and appear to play key roles in atherosclerosis. Lipoprotein-associated phospholipase A2 may also be an independent CVD risk factor. Psoriasis has been associated with an increasing risk for atherosclerosis, including coronary artery disease and stroke. Patients with psoriasis have a 5-year shorter life expectancy, most frequently due to CVD. Psoriasis is associated with a chronic inflammatory state and with elevated levels of CRP and other inflammatory cytokines and these may play a causative role in the increased risk of psoriatic patients for CVD. Patients with psoriasis may represent an emerging risk population and patients with moderate to severe psoriasis should be screened and aggressively treated for CVD risk factors.
KW - C-reactive protein
KW - Coronary artery disease
KW - Inflammatory biomarkers
KW - Lipoprotein-associated phospholipase A
KW - Psoriasis
KW - Toll-like receptors
UR - http://www.scopus.com/inward/record.url?scp=84879498052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879498052&partnerID=8YFLogxK
U2 - 10.1007/s12016-012-8308-0
DO - 10.1007/s12016-012-8308-0
M3 - Article
C2 - 22359071
AN - SCOPUS:84879498052
VL - 44
SP - 194
EP - 204
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 2
ER -