Inflammation, atherosclerosis, and psoriasis

David Siegel, Sridevi Devaraj, Anupam Mitra, Siba P Raychaudhuri, Smriti K. Raychaudhuri, Ishwarlal Jialal

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Increasing evidence supports an important role for inflammation in all phases of atherosclerosis, from initiation of the fatty streak to final culmination in acute coronary syndromes. Numerous inflammatory biomarkers including cell adhesion molecules, cytokines, chemokines, and acute-phase reactants such as fibrinogen, serum amyloid A, and C-reactive protein (CRP) have been shown to predict cardiovascular (CVD) events. Several prospective studies have shown a consistent and robust relationship between levels of high-sensitivity CRP and the risk of future CVD events. Toll-like receptors are pattern recognition receptors and members of the innate immune system that contribute to inflammation and appear to play key roles in atherosclerosis. Lipoprotein-associated phospholipase A2 may also be an independent CVD risk factor. Psoriasis has been associated with an increasing risk for atherosclerosis, including coronary artery disease and stroke. Patients with psoriasis have a 5-year shorter life expectancy, most frequently due to CVD. Psoriasis is associated with a chronic inflammatory state and with elevated levels of CRP and other inflammatory cytokines and these may play a causative role in the increased risk of psoriatic patients for CVD. Patients with psoriasis may represent an emerging risk population and patients with moderate to severe psoriasis should be screened and aggressively treated for CVD risk factors.

Original languageEnglish (US)
Pages (from-to)194-204
Number of pages11
JournalClinical Reviews in Allergy and Immunology
Volume44
Issue number2
DOIs
StatePublished - 2013

Fingerprint

Psoriasis
Atherosclerosis
Inflammation
C-Reactive Protein
1-Alkyl-2-acetylglycerophosphocholine Esterase
Cytokines
Pattern Recognition Receptors
Serum Amyloid A Protein
Acute-Phase Proteins
Toll-Like Receptors
Cell Adhesion Molecules
Acute Coronary Syndrome
Life Expectancy
Chemokines
Fibrinogen
Coronary Artery Disease
Immune System
Biomarkers
Stroke
Prospective Studies

Keywords

  • C-reactive protein
  • Coronary artery disease
  • Inflammatory biomarkers
  • Lipoprotein-associated phospholipase A
  • Psoriasis
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Inflammation, atherosclerosis, and psoriasis. / Siegel, David; Devaraj, Sridevi; Mitra, Anupam; Raychaudhuri, Siba P; Raychaudhuri, Smriti K.; Jialal, Ishwarlal.

In: Clinical Reviews in Allergy and Immunology, Vol. 44, No. 2, 2013, p. 194-204.

Research output: Contribution to journalArticle

Siegel, David ; Devaraj, Sridevi ; Mitra, Anupam ; Raychaudhuri, Siba P ; Raychaudhuri, Smriti K. ; Jialal, Ishwarlal. / Inflammation, atherosclerosis, and psoriasis. In: Clinical Reviews in Allergy and Immunology. 2013 ; Vol. 44, No. 2. pp. 194-204.
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