Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia

Willem J. Kop, John S. Gottdiener, Catherine M. Tangen, Linda P. Fried, Mary Ann McBurnie, Jeremy Walston, Anne Newman, Calvin H Hirsch, Russell P. Tracy

Research output: Contribution to journalArticle

268 Citations (Scopus)

Abstract

Depression is associated with increased cardiovascular disease, but the underlying mechanisms are not well understood. This study examines associations of depressive symptoms with inflammation and coagulation factors in persons aged >65 years. Blood samples were obtained from 4,268 subjects free of cardiovascular disease (age 72.4 ± 5.5 years, 2,623 women). Inflammation markers were C-reactive protein (CRP), white blood cell (WBC) count, total platelet count, and albumin; coagulation factors included factors VIIc and VIIIc and fibrinogen. Depression was assessed with the Center for Epidemiologic Studies Depression scale, and states of energy depletion with a validated exhaustion index. Statistical adjustments were made for risk factors (age, sex, race, systolic blood pressure, smoking status, diabetes mellitus) and physical measures of frailty (isometric handgrip, timed 15-feet walk test, activity level). Depression was associated with elevated CRP (3.31 ± 0.10 vs 3.51 ± 0.21 mg/L), WBC (6.14 ± 0.03 vs 6.43 ± 0.11 106/L), fibrinogen (319 ± 1 vs 326 ± 3 mg/dl), and factor VIIc (124.6 ± 0.6% vs 127.2 ± 1.3%; all p < 0.05). Exhaustion also was related to elevated inflammation and coagulation markers (p < 0.05). Exhausted men had markedly elevated CRP levels (6.82 ± 2.10 mg/L) versus nonexhausted men (3.05 ± 0.16: p = 0.007). After adjustment for control variables, exhaustion remained associated with albumin (p = 0.033), fibrinogen (p = 0.017), CRP (p = 0.066), and WBC (p = 0.060), whereas associations of depressive symptoms with biochemistry measures lost statistical significance. Thus, depression and exhaustion are associated with low-grade inflammation and elevated coagulation factors in persons aged >65 years.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalAmerican Journal of Cardiology
Volume89
Issue number4
DOIs
StatePublished - Feb 15 2002

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Blood Coagulation Factors
Myocardial Ischemia
Depression
Inflammation
C-Reactive Protein
Fibrinogen
Cardiovascular Diseases
Blood Pressure
Social Adjustment
Platelet Count
Leukocyte Count
Epidemiologic Studies
Albumins
Diabetes Mellitus
Leukocytes
Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia. / Kop, Willem J.; Gottdiener, John S.; Tangen, Catherine M.; Fried, Linda P.; McBurnie, Mary Ann; Walston, Jeremy; Newman, Anne; Hirsch, Calvin H; Tracy, Russell P.

In: American Journal of Cardiology, Vol. 89, No. 4, 15.02.2002, p. 419-424.

Research output: Contribution to journalArticle

Kop, Willem J. ; Gottdiener, John S. ; Tangen, Catherine M. ; Fried, Linda P. ; McBurnie, Mary Ann ; Walston, Jeremy ; Newman, Anne ; Hirsch, Calvin H ; Tracy, Russell P. / Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia. In: American Journal of Cardiology. 2002 ; Vol. 89, No. 4. pp. 419-424.
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abstract = "Depression is associated with increased cardiovascular disease, but the underlying mechanisms are not well understood. This study examines associations of depressive symptoms with inflammation and coagulation factors in persons aged >65 years. Blood samples were obtained from 4,268 subjects free of cardiovascular disease (age 72.4 ± 5.5 years, 2,623 women). Inflammation markers were C-reactive protein (CRP), white blood cell (WBC) count, total platelet count, and albumin; coagulation factors included factors VIIc and VIIIc and fibrinogen. Depression was assessed with the Center for Epidemiologic Studies Depression scale, and states of energy depletion with a validated exhaustion index. Statistical adjustments were made for risk factors (age, sex, race, systolic blood pressure, smoking status, diabetes mellitus) and physical measures of frailty (isometric handgrip, timed 15-feet walk test, activity level). Depression was associated with elevated CRP (3.31 ± 0.10 vs 3.51 ± 0.21 mg/L), WBC (6.14 ± 0.03 vs 6.43 ± 0.11 106/L), fibrinogen (319 ± 1 vs 326 ± 3 mg/dl), and factor VIIc (124.6 ± 0.6{\%} vs 127.2 ± 1.3{\%}; all p < 0.05). Exhaustion also was related to elevated inflammation and coagulation markers (p < 0.05). Exhausted men had markedly elevated CRP levels (6.82 ± 2.10 mg/L) versus nonexhausted men (3.05 ± 0.16: p = 0.007). After adjustment for control variables, exhaustion remained associated with albumin (p = 0.033), fibrinogen (p = 0.017), CRP (p = 0.066), and WBC (p = 0.060), whereas associations of depressive symptoms with biochemistry measures lost statistical significance. Thus, depression and exhaustion are associated with low-grade inflammation and elevated coagulation factors in persons aged >65 years.",
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AU - Fried, Linda P.

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AU - Walston, Jeremy

AU - Newman, Anne

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AU - Tracy, Russell P.

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