Inflammation and cardiometabolic risk in African American women is reduced by a pilot community-based educational intervention

Amparo C Villablanca, Cris Warford, Kellie Wheeler

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: Cardiovascular disease (CVD) is the leading cause of death for women, and African Americans have higher rates of CVD mortality than do other racio/ethnic groups. Women in community settings can benefit from preventive interventions, yet few investigations of successful programs have been conducted and evaluated in high-risk women, especially for metabolic syndrome. The purpose of our study was to pilot and assess the effectiveness of a 4-month pre-/post-CVD preventive educational intervention in improving knowledge, clinical risk profiles, adoption of heart-healthy lifestyles, inflammatory burden, and cardiometabolic risk in African American women in local communities. Methods: Forty-two African American women (mean age 59 years) enrolled in the 4-month educational Cardiovascular Disease Preventive Intervention Program in Sacramento, CA, in 2010. Participants completed knowledge-based surveys pre-/postintervention, provided clinical measures (weight, waist circumference, body mass index (BMI), blood pressure and blood samples for analysis of fasting glucose and lipids, and inflammatory markers: tumor necrosis factor (TNF)-α±, high-sensitivity C-reactive protein (hs-CRP), and interleukin (IL)-12. Results: The CVD risk profile of participants confirmed a high-risk cohort. Postintervention (n=31), there were significant (p<0.05) gains in knowledge for all symptoms of a heart attack and calling 911; improvements in clinical risk parameters, especially for waist circumference and low-density lipoprotein (LDL) cholesterol (p<0.05); and reductions in all the inflammatory markers assessed: TNF-α±by 16%, IL-12 by 20%, and hs-CRP by 26% (p<0.05). There was also a 60% reduction in the number of participants with metabolic syndrome (MetS) (p<0.05), driven primarily by reductions in triglycerides and glucose and a rise in high-density lipoprotein (HDL) cholesterol. Conclusions: We demonstrated the efficacy of a pilot community-based educational cardiovascular program in reducing cardiometabolic risk and inflammation in high-risk African American women. Our successful culturally appropriate and sustainable model could be implemented as part of comprehensive efforts to improve community-based health outcomes.

Original languageEnglish (US)
Pages (from-to)188-199
Number of pages12
JournalJournal of Women's Health
Issue number2
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Medicine(all)


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