Inferior Temporal, Prefrontal, and Hippocampal Contributions to Visual Working Memory Maintenance and Associative Memory Retrieval

Charan Ranganath, Michael X. Cohen, Cathrine Dam, Mark D'Esposito

Research output: Contribution to journalArticle

243 Scopus citations

Abstract

Higher order cognition depends on the ability to recall information from memory and hold it in mind to guide future behavior. To specify the neural mechanisms underlying these processes, we used event-related functional magnetic resonance imaging to compare brain activity during the performance of a visual associative memory task and a visual working memory task. Activity within category-selective subregions of inferior temporal cortex reflected the type of information that was actively maintained during both the associative memory and working memory tasks. In addition, activity in the anterior prefrontal cortex and hippocampus was specifically enhanced during associative memory retrieval. These data are consistent with the view that the active maintenance of visual information is supported by activation of object representations in inferior temporal cortex, but that goal-directed associative memory retrieval additionally depends on top-down signals from the anterior prefrontal cortex and medial temporal lobes.

Original languageEnglish (US)
Pages (from-to)3917-3925
Number of pages9
JournalJournal of Neuroscience
Volume24
Issue number16
DOIs
StatePublished - Apr 21 2004

Keywords

  • Anterior
  • Associative
  • Control
  • Cortex
  • Dorsolateral
  • Episodic
  • Event related
  • Executive
  • fMRI
  • Frontal
  • Frontopolar
  • Inferior
  • Lobes
  • Long term
  • Memory
  • Neuroimaging
  • Prefrontal
  • Short term
  • Temporal
  • Ventrolateral
  • Visual
  • Working

ASJC Scopus subject areas

  • Neuroscience(all)

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