Infectious necrotic hepatitis (INH) is a lethal disease of sheep caused by Clostridium novyi type B. It may also affect cattle. This chapter discusses the etiology, pathogenesis, epidemiology, clinical signs, diagnosis, treatment and control of INH. C. novyi type B produces mainly alpha toxin and beta toxin, which are thought to be the main virulence factors of the microorganism. INH affects mainly adult animals, usually in good nutritional condition, with no apparent breed or sex predisposition. Sheep affected by the disease die within a few hours of disease onset and frequently without clinical signs being observed. In general, gross changes in sheep and cattle that die of INH are essentially similar to those described for BH, with a few exceptions. Vaccination against C. novyi type B and control of liver-fluke infestation is effective as a means of preventing or reducing the incidence of INH.
- Adult sheep
- C. novyi
- Infectious necrotic hepatitis
- Liver fluke infestation
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