Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter

R. Drolet, S. D'Allaire, R. Larochelle, R. Magar, M. Ribotta, Robert Higgins

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

One kidney was taken from each of 100 pigs at slaughter; 50 had gross lesions of multifocal interstitial nephritis and 50 had no gross lesions. Forty-nine of the affected kidneys had lesions that were characterised by the presence of either a few randomly distributed or numerous widely disseminated pale foci, 1 to 3 mm in diameter, on the cortical surface (white-dotted kidneys). Microscopically, these focal inflammatory lesions often had a distinct lymphofollicular pattern (follicular nephritis). Lesions of chronic vasculitis were observed in 21 of the affected kidneys. Histologically, the control kidneys had only small and sparse inflammatory foci. Standard bacterial cultures of kidneys of both groups were not significant, and cultures for the isolation of leptospires were all negative. Virological examination of the kidney homogenates by PCR did not reveal any porcine reproductive and respiratory syndrome virus and only a few cases were positive for the porcine circovirus type 1. However, porcine parvovirus (PPV) and porcine circovirus type 2 (PCV-2) were detected in many kidneys of both groups but in a significantly higher proportion of the kidneys with interstitial nephritis. There was a significant association between the lesions and the presence of PPV and PCV-2 with odds ratios of 7.5 (P<0.0001) and 3.4 (P=0.0074), respectively, and the odds ratio increased to 22.7 (P<0.0001) when both viruses were identified in the same kidney. However, a subsample of kidneys taken from both groups were negative by immunohistochemistry for the presence of PPV and PCV-2 antigens.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalVeterinary Record
Volume150
Issue number5
DOIs
StatePublished - Feb 2 2002
Externally publishedYes

Fingerprint

Interstitial Nephritis
nephritis
slaughter
Swine
kidneys
Kidney
swine
pathogens
lesions (animal)
Circovirus
Porcine Parvovirus
Ungulate protoparvovirus 1
Porcine circovirus-2
odds ratio
Porcine circovirus-1
Odds Ratio
Porcine respiratory and reproductive syndrome virus
vasculitis
Nephritis
Porcine reproductive and respiratory syndrome virus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter. / Drolet, R.; D'Allaire, S.; Larochelle, R.; Magar, R.; Ribotta, M.; Higgins, Robert.

In: Veterinary Record, Vol. 150, No. 5, 02.02.2002, p. 139-143.

Research output: Contribution to journalArticle

Drolet, R, D'Allaire, S, Larochelle, R, Magar, R, Ribotta, M & Higgins, R 2002, 'Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter', Veterinary Record, vol. 150, no. 5, pp. 139-143. https://doi.org/10.1136/vr.150.5.139
Drolet, R. ; D'Allaire, S. ; Larochelle, R. ; Magar, R. ; Ribotta, M. ; Higgins, Robert. / Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter. In: Veterinary Record. 2002 ; Vol. 150, No. 5. pp. 139-143.
@article{931b3469fdb34f18813f8c1f432d08a3,
title = "Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter",
abstract = "One kidney was taken from each of 100 pigs at slaughter; 50 had gross lesions of multifocal interstitial nephritis and 50 had no gross lesions. Forty-nine of the affected kidneys had lesions that were characterised by the presence of either a few randomly distributed or numerous widely disseminated pale foci, 1 to 3 mm in diameter, on the cortical surface (white-dotted kidneys). Microscopically, these focal inflammatory lesions often had a distinct lymphofollicular pattern (follicular nephritis). Lesions of chronic vasculitis were observed in 21 of the affected kidneys. Histologically, the control kidneys had only small and sparse inflammatory foci. Standard bacterial cultures of kidneys of both groups were not significant, and cultures for the isolation of leptospires were all negative. Virological examination of the kidney homogenates by PCR did not reveal any porcine reproductive and respiratory syndrome virus and only a few cases were positive for the porcine circovirus type 1. However, porcine parvovirus (PPV) and porcine circovirus type 2 (PCV-2) were detected in many kidneys of both groups but in a significantly higher proportion of the kidneys with interstitial nephritis. There was a significant association between the lesions and the presence of PPV and PCV-2 with odds ratios of 7.5 (P<0.0001) and 3.4 (P=0.0074), respectively, and the odds ratio increased to 22.7 (P<0.0001) when both viruses were identified in the same kidney. However, a subsample of kidneys taken from both groups were negative by immunohistochemistry for the presence of PPV and PCV-2 antigens.",
author = "R. Drolet and S. D'Allaire and R. Larochelle and R. Magar and M. Ribotta and Robert Higgins",
year = "2002",
month = "2",
day = "2",
doi = "10.1136/vr.150.5.139",
language = "English (US)",
volume = "150",
pages = "139--143",
journal = "Veterinary Record",
issn = "0042-4900",
publisher = "British Veterinary Association",
number = "5",

}

TY - JOUR

T1 - Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter

AU - Drolet, R.

AU - D'Allaire, S.

AU - Larochelle, R.

AU - Magar, R.

AU - Ribotta, M.

AU - Higgins, Robert

PY - 2002/2/2

Y1 - 2002/2/2

N2 - One kidney was taken from each of 100 pigs at slaughter; 50 had gross lesions of multifocal interstitial nephritis and 50 had no gross lesions. Forty-nine of the affected kidneys had lesions that were characterised by the presence of either a few randomly distributed or numerous widely disseminated pale foci, 1 to 3 mm in diameter, on the cortical surface (white-dotted kidneys). Microscopically, these focal inflammatory lesions often had a distinct lymphofollicular pattern (follicular nephritis). Lesions of chronic vasculitis were observed in 21 of the affected kidneys. Histologically, the control kidneys had only small and sparse inflammatory foci. Standard bacterial cultures of kidneys of both groups were not significant, and cultures for the isolation of leptospires were all negative. Virological examination of the kidney homogenates by PCR did not reveal any porcine reproductive and respiratory syndrome virus and only a few cases were positive for the porcine circovirus type 1. However, porcine parvovirus (PPV) and porcine circovirus type 2 (PCV-2) were detected in many kidneys of both groups but in a significantly higher proportion of the kidneys with interstitial nephritis. There was a significant association between the lesions and the presence of PPV and PCV-2 with odds ratios of 7.5 (P<0.0001) and 3.4 (P=0.0074), respectively, and the odds ratio increased to 22.7 (P<0.0001) when both viruses were identified in the same kidney. However, a subsample of kidneys taken from both groups were negative by immunohistochemistry for the presence of PPV and PCV-2 antigens.

AB - One kidney was taken from each of 100 pigs at slaughter; 50 had gross lesions of multifocal interstitial nephritis and 50 had no gross lesions. Forty-nine of the affected kidneys had lesions that were characterised by the presence of either a few randomly distributed or numerous widely disseminated pale foci, 1 to 3 mm in diameter, on the cortical surface (white-dotted kidneys). Microscopically, these focal inflammatory lesions often had a distinct lymphofollicular pattern (follicular nephritis). Lesions of chronic vasculitis were observed in 21 of the affected kidneys. Histologically, the control kidneys had only small and sparse inflammatory foci. Standard bacterial cultures of kidneys of both groups were not significant, and cultures for the isolation of leptospires were all negative. Virological examination of the kidney homogenates by PCR did not reveal any porcine reproductive and respiratory syndrome virus and only a few cases were positive for the porcine circovirus type 1. However, porcine parvovirus (PPV) and porcine circovirus type 2 (PCV-2) were detected in many kidneys of both groups but in a significantly higher proportion of the kidneys with interstitial nephritis. There was a significant association between the lesions and the presence of PPV and PCV-2 with odds ratios of 7.5 (P<0.0001) and 3.4 (P=0.0074), respectively, and the odds ratio increased to 22.7 (P<0.0001) when both viruses were identified in the same kidney. However, a subsample of kidneys taken from both groups were negative by immunohistochemistry for the presence of PPV and PCV-2 antigens.

UR - http://www.scopus.com/inward/record.url?scp=0037006359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037006359&partnerID=8YFLogxK

U2 - 10.1136/vr.150.5.139

DO - 10.1136/vr.150.5.139

M3 - Article

C2 - 11871667

AN - SCOPUS:0037006359

VL - 150

SP - 139

EP - 143

JO - Veterinary Record

JF - Veterinary Record

SN - 0042-4900

IS - 5

ER -