Abstract
Mycobacteria were isolated and characterised from 49 cats with extensive infections of the subcutis and skin. Cats were generally between 3 and 10 years of age, and female cats were markedly over-represented. All isolates were rapid-growers and identified as either Mycobacteria smegmatis (40 strains) or M fortuitum (nine strains). On the basis of Etest for minimum inhibitory concentration and/or disc diffusion susceptibility testing, all strains of M smegmatis were susceptible to trimethoprim while all strains of M fortuitum were resistant. M smegmatis strains were typically susceptible to doxycycline, gentamicin and fluoroquinolones but not clarithromycin. All M fortuitum strains were susceptible to fluoroquinolones, and often also susceptible to gentamicin, doxycycline and clarithromycin. Generally, M smegmatis strains were more susceptible to antimicrobial agents than M fortuitum strains. Treatment of mycobacterial panniculitis involves long courses of antimicrobial agents, typically of 3-6 months, chosen on the basis of in vitro susceptibility testing and often combined with extensive surgical debridement and wound reconstruction. These therapies will result in effective cure of the disease. One or a combination of doxycycline, ciprofloxacin/enrofloxacin or clarithromycin are the drugs of choice for long-term oral therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-48 |
| Number of pages | 14 |
| Journal | Journal of Feline Medicine and Surgery |
| Volume | 2 |
| Issue number | 1 |
| State | Published - Mar 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- veterinary(all)
Cite this
Infection of the subcutis and skin of cats with rapidly growing mycobacteria : A review of microbiological and clinical findings. / Malik, R.; Wigney, D. I.; Dawson, D.; Martin, P.; Hunt, Geraldine B; Love, D. N.
In: Journal of Feline Medicine and Surgery, Vol. 2, No. 1, 03.2000, p. 35-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infection of the subcutis and skin of cats with rapidly growing mycobacteria
T2 - A review of microbiological and clinical findings
AU - Malik, R.
AU - Wigney, D. I.
AU - Dawson, D.
AU - Martin, P.
AU - Hunt, Geraldine B
AU - Love, D. N.
PY - 2000/3
Y1 - 2000/3
N2 - Mycobacteria were isolated and characterised from 49 cats with extensive infections of the subcutis and skin. Cats were generally between 3 and 10 years of age, and female cats were markedly over-represented. All isolates were rapid-growers and identified as either Mycobacteria smegmatis (40 strains) or M fortuitum (nine strains). On the basis of Etest for minimum inhibitory concentration and/or disc diffusion susceptibility testing, all strains of M smegmatis were susceptible to trimethoprim while all strains of M fortuitum were resistant. M smegmatis strains were typically susceptible to doxycycline, gentamicin and fluoroquinolones but not clarithromycin. All M fortuitum strains were susceptible to fluoroquinolones, and often also susceptible to gentamicin, doxycycline and clarithromycin. Generally, M smegmatis strains were more susceptible to antimicrobial agents than M fortuitum strains. Treatment of mycobacterial panniculitis involves long courses of antimicrobial agents, typically of 3-6 months, chosen on the basis of in vitro susceptibility testing and often combined with extensive surgical debridement and wound reconstruction. These therapies will result in effective cure of the disease. One or a combination of doxycycline, ciprofloxacin/enrofloxacin or clarithromycin are the drugs of choice for long-term oral therapy.
AB - Mycobacteria were isolated and characterised from 49 cats with extensive infections of the subcutis and skin. Cats were generally between 3 and 10 years of age, and female cats were markedly over-represented. All isolates were rapid-growers and identified as either Mycobacteria smegmatis (40 strains) or M fortuitum (nine strains). On the basis of Etest for minimum inhibitory concentration and/or disc diffusion susceptibility testing, all strains of M smegmatis were susceptible to trimethoprim while all strains of M fortuitum were resistant. M smegmatis strains were typically susceptible to doxycycline, gentamicin and fluoroquinolones but not clarithromycin. All M fortuitum strains were susceptible to fluoroquinolones, and often also susceptible to gentamicin, doxycycline and clarithromycin. Generally, M smegmatis strains were more susceptible to antimicrobial agents than M fortuitum strains. Treatment of mycobacterial panniculitis involves long courses of antimicrobial agents, typically of 3-6 months, chosen on the basis of in vitro susceptibility testing and often combined with extensive surgical debridement and wound reconstruction. These therapies will result in effective cure of the disease. One or a combination of doxycycline, ciprofloxacin/enrofloxacin or clarithromycin are the drugs of choice for long-term oral therapy.
UR - http://www.scopus.com/inward/record.url?scp=0034158490&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034158490&partnerID=8YFLogxK
M3 - Article
C2 - 11716590
AN - SCOPUS:0034158490
VL - 2
SP - 35
EP - 48
JO - Journal of Feline Medicine and Surgery
JF - Journal of Feline Medicine and Surgery
SN - 1098-612X
IS - 1
ER -