Canine leishmaniasis is characterized by a clinical dichotomy between susceptible and resistant dogs, and by its systemic and fatal evolution in susceptible animals. This dichotomy may be related to the orientation of the T-helper lymphocyte response, i.e. a Th1-like response in resistant dogs, and a Th2-like response in susceptible dogs. The fact that antigen-presenting cells like Langerhans cells may play a role in the orientation of this immune response made it interesting to investigate the possibility that these cells, in dogs, can internalize Leishmania infantum. Immunostaining using an anti-canine CD1c monoclonal antibody on frozen sections, and cell preparations of skin and lymph nodes, from naturally-infected dogs allowed demonstration that CD1c+ cells, i.e. Langerhans cells, could be parasitized by L. infantum.
|Original language||English (US)|
|Number of pages||8|
|Journal||Revue de Medecine Veterinaire|
|State||Published - 1997|
- Langerhans cell interdigitating dendritic cell
- Leishmania infantum
ASJC Scopus subject areas