Infection of canine Langerhans cell and interdigitating dendritic cell by Leishmania infantum in spontaneous canine leishmaniasis 1 (2)

I. Saint-André Marchal, T. Marchai, Peter F Moore, J. P. Magnol, G. Bourdoiseau

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Canine leishmaniasis is characterized by a clinical dichotomy between susceptible and resistant dogs, and by its systemic and fatal evolution in susceptible animals. This dichotomy may be related to the orientation of the T-helper lymphocyte response, i.e. a Th1-like response in resistant dogs, and a Th2-like response in susceptible dogs. The fact that antigen-presenting cells like Langerhans cells may play a role in the orientation of this immune response made it interesting to investigate the possibility that these cells, in dogs, can internalize Leishmania infantum. Immunostaining using an anti-canine CD1c monoclonal antibody on frozen sections, and cell preparations of skin and lymph nodes, from naturally-infected dogs allowed demonstration that CD1c+ cells, i.e. Langerhans cells, could be parasitized by L. infantum.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalRevue de Medecine Veterinaire
Volume148
Issue number1
StatePublished - 1997

Keywords

  • Dog
  • Langerhans cell interdigitating dendritic cell
  • Leishmania infantum

ASJC Scopus subject areas

  • veterinary(all)

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