Abstract
Peripheral mononuclear cells from more than 160 persons from groups at risk for the acquired immunodeficiency syndrome (AIDS) have yielded AIDS-associated retroviruses (ARV). Antibodies to ARV can also be found in these risk groups. Antibody-negative, virus-positive persons have been identified with early infection or possible viremia with immune complex formation. Established lines of human T and B cells, monocytes, and promyelocytes have been infected with ARV. Moreover, infectious virus has been recovered from macrophages cultured from the blood of some persons with AIDS. The cytopathic effects of ARV in T cells is associated with the accumulation of unintegrated viral forms in the infected cells. The ARV has also been isolated from plasma, serum, saliva, semen, urine, cerebrospinal fluid, and brain tissue. All these results reflect the wide host range of ARV and support its role in neurologic abnormalities seen in some patients. Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region. All these features place ARV in the lentivirus subfamily or human retroviruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 694-699 |
| Number of pages | 6 |
| Journal | Annals of Internal Medicine |
| Volume | 103 |
| Issue number | 5 |
| State | Published - 1985 |
| Externally published | Yes |
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Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features. / Levy, J. A.; Kaminsky, L. S.; Morrow, W. J W; Steimer, K.; Luciw, Paul A; Dina, D.; Hoxie, J.; Oshiro, L.
In: Annals of Internal Medicine, Vol. 103, No. 5, 1985, p. 694-699.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features
AU - Levy, J. A.
AU - Kaminsky, L. S.
AU - Morrow, W. J W
AU - Steimer, K.
AU - Luciw, Paul A
AU - Dina, D.
AU - Hoxie, J.
AU - Oshiro, L.
PY - 1985
Y1 - 1985
N2 - Peripheral mononuclear cells from more than 160 persons from groups at risk for the acquired immunodeficiency syndrome (AIDS) have yielded AIDS-associated retroviruses (ARV). Antibodies to ARV can also be found in these risk groups. Antibody-negative, virus-positive persons have been identified with early infection or possible viremia with immune complex formation. Established lines of human T and B cells, monocytes, and promyelocytes have been infected with ARV. Moreover, infectious virus has been recovered from macrophages cultured from the blood of some persons with AIDS. The cytopathic effects of ARV in T cells is associated with the accumulation of unintegrated viral forms in the infected cells. The ARV has also been isolated from plasma, serum, saliva, semen, urine, cerebrospinal fluid, and brain tissue. All these results reflect the wide host range of ARV and support its role in neurologic abnormalities seen in some patients. Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region. All these features place ARV in the lentivirus subfamily or human retroviruses.
AB - Peripheral mononuclear cells from more than 160 persons from groups at risk for the acquired immunodeficiency syndrome (AIDS) have yielded AIDS-associated retroviruses (ARV). Antibodies to ARV can also be found in these risk groups. Antibody-negative, virus-positive persons have been identified with early infection or possible viremia with immune complex formation. Established lines of human T and B cells, monocytes, and promyelocytes have been infected with ARV. Moreover, infectious virus has been recovered from macrophages cultured from the blood of some persons with AIDS. The cytopathic effects of ARV in T cells is associated with the accumulation of unintegrated viral forms in the infected cells. The ARV has also been isolated from plasma, serum, saliva, semen, urine, cerebrospinal fluid, and brain tissue. All these results reflect the wide host range of ARV and support its role in neurologic abnormalities seen in some patients. Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region. All these features place ARV in the lentivirus subfamily or human retroviruses.
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M3 - Article
C2 - 2996401
AN - SCOPUS:0022408893
VL - 103
SP - 694
EP - 699
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
SN - 0003-4819
IS - 5
ER -