Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features

J. A. Levy, L. S. Kaminsky, W. J W Morrow, K. Steimer, Paul A Luciw, D. Dina, J. Hoxie, L. Oshiro

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

Peripheral mononuclear cells from more than 160 persons from groups at risk for the acquired immunodeficiency syndrome (AIDS) have yielded AIDS-associated retroviruses (ARV). Antibodies to ARV can also be found in these risk groups. Antibody-negative, virus-positive persons have been identified with early infection or possible viremia with immune complex formation. Established lines of human T and B cells, monocytes, and promyelocytes have been infected with ARV. Moreover, infectious virus has been recovered from macrophages cultured from the blood of some persons with AIDS. The cytopathic effects of ARV in T cells is associated with the accumulation of unintegrated viral forms in the infected cells. The ARV has also been isolated from plasma, serum, saliva, semen, urine, cerebrospinal fluid, and brain tissue. All these results reflect the wide host range of ARV and support its role in neurologic abnormalities seen in some patients. Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region. All these features place ARV in the lentivirus subfamily or human retroviruses.

Original languageEnglish (US)
Pages (from-to)694-699
Number of pages6
JournalAnnals of Internal Medicine
Volume103
Issue number5
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Levy, J. A., Kaminsky, L. S., Morrow, W. J. W., Steimer, K., Luciw, P. A., Dina, D., Hoxie, J., & Oshiro, L. (1985). Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features. Annals of Internal Medicine, 103(5), 694-699.