Ineffectiveness of dietary protein augmentation in the management of the nephrotic syndrome

Hamoudi Al-Bander, George Kaysen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The nephrotic syndrome is a consequence of altered permselectivity of the glomerular basement membrane resulting in urinary losses of albumin and other serum proteins. Although dietary protein augmentation increases albumin synthesis, it has not been shown to increase serum albumin or muscle protein. Dietary protein was increased from 8.5% to 21% in pair-fed rats with Heymann nephritis and resulted in an increase both in albumin synthesis and urinary albumin excretion, but not in serum albumin concentration or in total albumin pools. The increase in dietary protein was 8 times greater than the resulting increase in urinary protein excretion, but nearly all of the additional ingested protein was catabolized to urea and excreted in the urine rather than used to augment growth. Dietary supplementation with protein has no obvious beneficial effect on nutritional status of nephrotic rats.

Original languageEnglish (US)
Pages (from-to)482-486
Number of pages5
JournalPediatric Nephrology
Volume5
Issue number4
DOIs
StatePublished - Jul 1991

Keywords

  • Dietary protein augmentation
  • Nephrotic syndrome
  • Nutritional status

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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