Induction of type I diabetes by interferon-α in transgenic mice

T. A. Stewart, B. Hultgren, X. Huang, S. Pitts-Meek, J. Hully, Nigel J Maclachlan

Research output: Contribution to journalArticle

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Abstract

Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic β cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing β cells expressed an interferon-α. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-α. Thus, the expression of interferon-α by the β cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease.

Original languageEnglish (US)
Pages (from-to)1942-1946
Number of pages5
JournalScience
Volume260
Issue number5116
StatePublished - 1993

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Type 1 Diabetes Mellitus
Interferons
Transgenic Mice
Inflammation
Interferon Type I
Virus Diseases
Neutralizing Antibodies
Epigenomics
Autoimmune Diseases
Immune System
Insulin
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Stewart, T. A., Hultgren, B., Huang, X., Pitts-Meek, S., Hully, J., & Maclachlan, N. J. (1993). Induction of type I diabetes by interferon-α in transgenic mice. Science, 260(5116), 1942-1946.

Induction of type I diabetes by interferon-α in transgenic mice. / Stewart, T. A.; Hultgren, B.; Huang, X.; Pitts-Meek, S.; Hully, J.; Maclachlan, Nigel J.

In: Science, Vol. 260, No. 5116, 1993, p. 1942-1946.

Research output: Contribution to journalArticle

Stewart, TA, Hultgren, B, Huang, X, Pitts-Meek, S, Hully, J & Maclachlan, NJ 1993, 'Induction of type I diabetes by interferon-α in transgenic mice', Science, vol. 260, no. 5116, pp. 1942-1946.
Stewart TA, Hultgren B, Huang X, Pitts-Meek S, Hully J, Maclachlan NJ. Induction of type I diabetes by interferon-α in transgenic mice. Science. 1993;260(5116):1942-1946.
Stewart, T. A. ; Hultgren, B. ; Huang, X. ; Pitts-Meek, S. ; Hully, J. ; Maclachlan, Nigel J. / Induction of type I diabetes by interferon-α in transgenic mice. In: Science. 1993 ; Vol. 260, No. 5116. pp. 1942-1946.
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