Abstract
Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-122 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 100 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - May 22 1989 |
| Externally published | Yes |
Keywords
- c-Fos
- Cortical lesion
- Nerve growth factor
- Rat
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Sharp, F. R., Gonzalez, M. F., Hisanaga, K., Mobley, W. C., & Sagar, S. M. (1989). Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. Neuroscience Letters, 100(1-3), 117-122. https://doi.org/10.1016/0304-3940(89)90670-8