Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections

Frank R Sharp, Manuel F. Gonzalez, Kinya Hisanaga, William C. Mobley, Stephen M. Sagar

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalNeuroscience Letters
Volume100
Issue number1-3
DOIs
StatePublished - May 22 1989
Externally publishedYes

Keywords

  • c-Fos
  • Cortical lesion
  • Nerve growth factor
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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