Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections

Frank R Sharp; Manuel F. Gonzalez; Kinya Hisanaga; William C. Mobley; Stephen M. Sagar

doi:10.1016/0304-3940(89)90670-8

Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections

Frank R Sharp, Manuel F. Gonzalez, Kinya Hisanaga, William C. Mobley, Stephen M. Sagar

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.

Original language	English (US)
Pages (from-to)	117-122
Number of pages	6
Journal	Neuroscience Letters
Volume	100
Issue number	1-3
DOIs	https://doi.org/10.1016/0304-3940(89)90670-8
State	Published - May 22 1989
Externally published	Yes

Keywords

c-Fos
Cortical lesion
Nerve growth factor
Rat

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.",

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AU - Sagar, Stephen M.

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AB - Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.

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