Neocortical lesions and NGF injections into neocortex induce the immunostaining of Fos, the c-fos gene product, in neuronal nuclei in ipsilateral cortex, and amygdala. Adjacent structures including hippocampus, septal nuclei, globus pallidus, and thalamus were unaffected. It is hypothesized that trophic molecules or other chemicals are released at the injury site and these induce the c-fos gene in cells throughout the ipsilateral hemisphere. Fos induction might mediate metabolic or plasticity responses to the focal injury.
- Cortical lesion
- Nerve growth factor
ASJC Scopus subject areas
Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. / Sharp, Frank R; Gonzalez, Manuel F.; Hisanaga, Kinya; Mobley, William C.; Sagar, Stephen M.In: Neuroscience Letters, Vol. 100, No. 1-3, 22.05.1989, p. 117-122.
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