Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity

Hungyi Shau, Alejandro Merino, Lawrence Chen, Charles C.Y. Shih, Steven D Colquhoun

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalAntioxidants and Redox Signaling
Volume2
Issue number2
StatePublished - Jun 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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