Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity

Hungyi Shau; Alejandro Merino; Lawrence Chen; Charles C.Y. Shih; Steven D Colquhoun

Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity

Hungyi Shau, Alejandro Merino, Lawrence Chen, Charles C.Y. Shih, Steven D Colquhoun

Research output: Contribution to journal › Article › peer-review

Abstract

Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.

Original language	English (US)
Pages (from-to)	347-354
Number of pages	8
Journal	Antioxidants and Redox Signaling
Volume	2
Issue number	2
State	Published - Jun 1 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology

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title = "Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity",

abstract = "Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.",

author = "Hungyi Shau and Alejandro Merino and Lawrence Chen and Shih, {Charles C.Y.} and Colquhoun, {Steven D}",

year = "2000",

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language = "English (US)",

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T1 - Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity

AU - Shau, Hungyi

AU - Merino, Alejandro

AU - Chen, Lawrence

AU - Shih, Charles C.Y.

AU - Colquhoun, Steven D

PY - 2000/6/1

Y1 - 2000/6/1

N2 - Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.

AB - Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.

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