Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: In situ hybridization study

Hiroyuki Kinouchi; Frank R Sharp; Pak H. Chan; Jari Koistinaho; Stephen M. Sagar; Takashi Yoshimoto

doi:10.1016/0304-3940(94)90630-0

Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: In situ hybridization study

Hiroyuki Kinouchi, Frank R Sharp, Pak H. Chan, Jari Koistinaho, Stephen M. Sagar, Takashi Yoshimoto

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.

Original language	English (US)
Pages (from-to)	163-166
Number of pages	4
Journal	Neuroscience Letters
Volume	171
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90630-0
State	Published - Apr 25 1994
Externally published	Yes

Keywords

Central nervous system
Immediate early gene
Ischemia
Stroke
Zinc finger

ASJC Scopus subject areas

Neuroscience(all)

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title = "Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: In situ hybridization study",

abstract = "Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.",

keywords = "Central nervous system, Immediate early gene, Ischemia, Stroke, Zinc finger",

author = "Hiroyuki Kinouchi and Sharp, {Frank R} and Chan, {Pak H.} and Jari Koistinaho and Sagar, {Stephen M.} and Takashi Yoshimoto",

year = "1994",

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doi = "10.1016/0304-3940(94)90630-0",

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volume = "171",

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T2 - In situ hybridization study

AU - Kinouchi, Hiroyuki

AU - Sharp, Frank R

AU - Chan, Pak H.

AU - Koistinaho, Jari

AU - Sagar, Stephen M.

AU - Yoshimoto, Takashi

PY - 1994/4/25

Y1 - 1994/4/25

N2 - Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.

AB - Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.

KW - Central nervous system

KW - Immediate early gene

KW - Ischemia

KW - Stroke

KW - Zinc finger

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Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: In situ hybridization study

Abstract

Keywords

ASJC Scopus subject areas

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