Abstract
Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-166 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 171 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Apr 25 1994 |
| Externally published | Yes |
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Keywords
- Central nervous system
- Immediate early gene
- Ischemia
- Stroke
- Zinc finger
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats : In situ hybridization study. / Kinouchi, Hiroyuki; Sharp, Frank R; Chan, Pak H.; Koistinaho, Jari; Sagar, Stephen M.; Yoshimoto, Takashi.
In: Neuroscience Letters, Vol. 171, No. 1-2, 25.04.1994, p. 163-166.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats
T2 - In situ hybridization study
AU - Kinouchi, Hiroyuki
AU - Sharp, Frank R
AU - Chan, Pak H.
AU - Koistinaho, Jari
AU - Sagar, Stephen M.
AU - Yoshimoto, Takashi
PY - 1994/4/25
Y1 - 1994/4/25
N2 - Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.
AB - Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction.
KW - Central nervous system
KW - Immediate early gene
KW - Ischemia
KW - Stroke
KW - Zinc finger
UR - http://www.scopus.com/inward/record.url?scp=0028273278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028273278&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)90630-0
DO - 10.1016/0304-3940(94)90630-0
M3 - Article
C2 - 8084481
AN - SCOPUS:0028273278
VL - 171
SP - 163
EP - 166
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -