Induction of neuropilins-1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system

Marina Scarlato, Jahan Ara, Peter Bannerman, Steven Scherer, David E Pleasure

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The neuropilins, NP-1 and NP-2, are coreceptors for Sema3A and Sema3F, respectively, both of which are repulsive axonal guidance molecules. NP-1 and NP-2 are also coreceptors for vascular endothelial growth factor (VEGF). The neuropilins and their ligands are known to play prominent roles in axonal pathfinding, fasciculation, and blood vessel formation during peripheral nervous system (PNS) development. We confirmed a prior report (Exp. Neurol. 172 (2001) 398) that VEGF mRNA levels rise during Wallerian degeneration in the PNS and herein demonstrate that NP-1, NP-2, Sema3A, and Sema3F mRNA levels increase in peripheral nerves distal to a transection or crush injury. In a sciatic nerve crush model, in which axonal regeneration is robust, the highest levels of Sema3F mRNA below the injury site are in the epi- and perineurium. Our results suggest the possibility that the neuropilins and their semaphorin ligands serve to guide, rather than to impede, regenerating axons in the adult PNS.

Original languageEnglish (US)
Pages (from-to)489-498
Number of pages10
JournalExperimental Neurology
Volume183
Issue number2
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

Fingerprint

Neuropilin-2
Semaphorin-3A
Neuropilin-1
Wallerian Degeneration
Peripheral Nervous System
Neuropilins
Peripheral Nerves
Vascular Endothelial Growth Factor A
Ligands
Messenger RNA
Semaphorins
Nerve Crush
Sciatic Nerve
Blood Vessels
Axons
Regeneration
Wounds and Injuries

Keywords

  • Axonal guidance
  • Neuropilin
  • Sciatic nerve
  • Semaphorin
  • Wallerian degeneration

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Induction of neuropilins-1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system. / Scarlato, Marina; Ara, Jahan; Bannerman, Peter; Scherer, Steven; Pleasure, David E.

In: Experimental Neurology, Vol. 183, No. 2, 01.10.2003, p. 489-498.

Research output: Contribution to journalArticle

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AB - The neuropilins, NP-1 and NP-2, are coreceptors for Sema3A and Sema3F, respectively, both of which are repulsive axonal guidance molecules. NP-1 and NP-2 are also coreceptors for vascular endothelial growth factor (VEGF). The neuropilins and their ligands are known to play prominent roles in axonal pathfinding, fasciculation, and blood vessel formation during peripheral nervous system (PNS) development. We confirmed a prior report (Exp. Neurol. 172 (2001) 398) that VEGF mRNA levels rise during Wallerian degeneration in the PNS and herein demonstrate that NP-1, NP-2, Sema3A, and Sema3F mRNA levels increase in peripheral nerves distal to a transection or crush injury. In a sciatic nerve crush model, in which axonal regeneration is robust, the highest levels of Sema3F mRNA below the injury site are in the epi- and perineurium. Our results suggest the possibility that the neuropilins and their semaphorin ligands serve to guide, rather than to impede, regenerating axons in the adult PNS.

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KW - Wallerian degeneration

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