Induction of marginal zinc deficiency in female rhesus monkeys

M. S. Golub, M. Eric Gershwin, Andrew G Hendrickx

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although severe zinc deficiency has been previously induced in rhesus monkeys, marginal zinc deprivation, a state more analogous to that found in human populations has not been characterized. To address this issue, zinc deficiency was induced in mature female rhesus monkeys by restriction of dietary zinc in a semipurified diet based on sprayed egg white as the protein source. Groups of monkeys were fed dietary levels of 0.5, 2, 4, 8, 12, 20 or 100 ppm zinc. Plasma zinc concentration fell from an initial level of 92-148 μg/100 ml to levels between 40 and 90 μg/100 ml in monkeys fed 8 ppm zinc or less. This reduction in plasma zinc concentration was associated with alterations in peripheral blood lymphocyte mitogen responsiveness, taste sensitivity, and behavior similar to those seen in human zinc deficiency. However, in contrast to studies of severe zinc deprivation, our animals did not manifest alopecia, dermatitis, anorexia, or weight loss. It was concluded that marginal dietary zinc deficiency can be readily produced in primates and that depressed zinc levels achieved by this selective dietary restriction can lead to quantitative physiological changes without overt pathology. These findings are important for the development of a relevant animal model of marginal zinc deficiency.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalAmerican Journal of Primatology
Volume3
Issue number1-4
StatePublished - 1982

Fingerprint

Macaca mulatta
zinc
dietary restriction
monkeys
taste sensitivity
plasma
alopecia
animal
egg albumen
pathology
dermatitis
anorexia
primate
human population
protein sources
Primates
weight loss
lymphocytes
animal models
blood

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Induction of marginal zinc deficiency in female rhesus monkeys. / Golub, M. S.; Gershwin, M. Eric; Hendrickx, Andrew G.

In: American Journal of Primatology, Vol. 3, No. 1-4, 1982, p. 299-305.

Research output: Contribution to journalArticle

Golub, M. S. ; Gershwin, M. Eric ; Hendrickx, Andrew G. / Induction of marginal zinc deficiency in female rhesus monkeys. In: American Journal of Primatology. 1982 ; Vol. 3, No. 1-4. pp. 299-305.
@article{a18ac26757c3495f8d63eff6d63dd9e1,
title = "Induction of marginal zinc deficiency in female rhesus monkeys",
abstract = "Although severe zinc deficiency has been previously induced in rhesus monkeys, marginal zinc deprivation, a state more analogous to that found in human populations has not been characterized. To address this issue, zinc deficiency was induced in mature female rhesus monkeys by restriction of dietary zinc in a semipurified diet based on sprayed egg white as the protein source. Groups of monkeys were fed dietary levels of 0.5, 2, 4, 8, 12, 20 or 100 ppm zinc. Plasma zinc concentration fell from an initial level of 92-148 μg/100 ml to levels between 40 and 90 μg/100 ml in monkeys fed 8 ppm zinc or less. This reduction in plasma zinc concentration was associated with alterations in peripheral blood lymphocyte mitogen responsiveness, taste sensitivity, and behavior similar to those seen in human zinc deficiency. However, in contrast to studies of severe zinc deprivation, our animals did not manifest alopecia, dermatitis, anorexia, or weight loss. It was concluded that marginal dietary zinc deficiency can be readily produced in primates and that depressed zinc levels achieved by this selective dietary restriction can lead to quantitative physiological changes without overt pathology. These findings are important for the development of a relevant animal model of marginal zinc deficiency.",
author = "Golub, {M. S.} and Gershwin, {M. Eric} and Hendrickx, {Andrew G}",
year = "1982",
language = "English (US)",
volume = "3",
pages = "299--305",
journal = "American Journal of Primatology",
issn = "0275-2565",
publisher = "John Wiley and Sons Inc.",
number = "1-4",

}

TY - JOUR

T1 - Induction of marginal zinc deficiency in female rhesus monkeys

AU - Golub, M. S.

AU - Gershwin, M. Eric

AU - Hendrickx, Andrew G

PY - 1982

Y1 - 1982

N2 - Although severe zinc deficiency has been previously induced in rhesus monkeys, marginal zinc deprivation, a state more analogous to that found in human populations has not been characterized. To address this issue, zinc deficiency was induced in mature female rhesus monkeys by restriction of dietary zinc in a semipurified diet based on sprayed egg white as the protein source. Groups of monkeys were fed dietary levels of 0.5, 2, 4, 8, 12, 20 or 100 ppm zinc. Plasma zinc concentration fell from an initial level of 92-148 μg/100 ml to levels between 40 and 90 μg/100 ml in monkeys fed 8 ppm zinc or less. This reduction in plasma zinc concentration was associated with alterations in peripheral blood lymphocyte mitogen responsiveness, taste sensitivity, and behavior similar to those seen in human zinc deficiency. However, in contrast to studies of severe zinc deprivation, our animals did not manifest alopecia, dermatitis, anorexia, or weight loss. It was concluded that marginal dietary zinc deficiency can be readily produced in primates and that depressed zinc levels achieved by this selective dietary restriction can lead to quantitative physiological changes without overt pathology. These findings are important for the development of a relevant animal model of marginal zinc deficiency.

AB - Although severe zinc deficiency has been previously induced in rhesus monkeys, marginal zinc deprivation, a state more analogous to that found in human populations has not been characterized. To address this issue, zinc deficiency was induced in mature female rhesus monkeys by restriction of dietary zinc in a semipurified diet based on sprayed egg white as the protein source. Groups of monkeys were fed dietary levels of 0.5, 2, 4, 8, 12, 20 or 100 ppm zinc. Plasma zinc concentration fell from an initial level of 92-148 μg/100 ml to levels between 40 and 90 μg/100 ml in monkeys fed 8 ppm zinc or less. This reduction in plasma zinc concentration was associated with alterations in peripheral blood lymphocyte mitogen responsiveness, taste sensitivity, and behavior similar to those seen in human zinc deficiency. However, in contrast to studies of severe zinc deprivation, our animals did not manifest alopecia, dermatitis, anorexia, or weight loss. It was concluded that marginal dietary zinc deficiency can be readily produced in primates and that depressed zinc levels achieved by this selective dietary restriction can lead to quantitative physiological changes without overt pathology. These findings are important for the development of a relevant animal model of marginal zinc deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0020379375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020379375&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0020379375

VL - 3

SP - 299

EP - 305

JO - American Journal of Primatology

JF - American Journal of Primatology

SN - 0275-2565

IS - 1-4

ER -