Abstract
The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 954-961 |
| Number of pages | 8 |
| Journal | Molecular and Cellular Biology |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1992 |
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene : A Transgenic Mouse Model for Metastatic Disease. / Guy, Chantale T.; Cardiff, Robert; Muller, William J.
In: Molecular and Cellular Biology, Vol. 12, No. 3, 01.01.1992, p. 954-961.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene
T2 - A Transgenic Mouse Model for Metastatic Disease
AU - Guy, Chantale T.
AU - Cardiff, Robert
AU - Muller, William J.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.
AB - The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026587657&partnerID=8YFLogxK
U2 - 10.1128/MCB.12.3.954
DO - 10.1128/MCB.12.3.954
M3 - Article
C2 - 1312220
AN - SCOPUS:0026587657
VL - 12
SP - 954
EP - 961
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
SN - 0270-7306
IS - 3
ER -