Abstract
IgE and IgG antibody responses to the trimellitate (TM) hapten group were elicited in mice by the intraperitoneal injection of the hapten coupled with keyhole limpet hemocyanin (KLH). Treatment of such previously sensitized mice with the same hapten coupled to synthetic copolymer of D-glutamic acid and D-lysine (D-GL) after primary immunization resulted in significant and specific suppression of anti-TM antibody responses in both IgE and IgG classes. These results provide direct evidence for the potential clinical usefulness of the D-GL immunotherapeutic approach to TMA sensitivity in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 322-326 |
| Number of pages | 5 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 66 |
| Issue number | 4 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Induction of immunologic tolerance to the trimellitate haptenic group in mice : Model for a therapeutic approach to trimellitic anhydride-induced hypersensitivity syndromes in humans? / Liu, Fu-Tong; Bargatze, R. F.; Katz, D. H.
In: Journal of Allergy and Clinical Immunology, Vol. 66, No. 4, 1980, p. 322-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of immunologic tolerance to the trimellitate haptenic group in mice
T2 - Model for a therapeutic approach to trimellitic anhydride-induced hypersensitivity syndromes in humans?
AU - Liu, Fu-Tong
AU - Bargatze, R. F.
AU - Katz, D. H.
PY - 1980
Y1 - 1980
N2 - IgE and IgG antibody responses to the trimellitate (TM) hapten group were elicited in mice by the intraperitoneal injection of the hapten coupled with keyhole limpet hemocyanin (KLH). Treatment of such previously sensitized mice with the same hapten coupled to synthetic copolymer of D-glutamic acid and D-lysine (D-GL) after primary immunization resulted in significant and specific suppression of anti-TM antibody responses in both IgE and IgG classes. These results provide direct evidence for the potential clinical usefulness of the D-GL immunotherapeutic approach to TMA sensitivity in humans.
AB - IgE and IgG antibody responses to the trimellitate (TM) hapten group were elicited in mice by the intraperitoneal injection of the hapten coupled with keyhole limpet hemocyanin (KLH). Treatment of such previously sensitized mice with the same hapten coupled to synthetic copolymer of D-glutamic acid and D-lysine (D-GL) after primary immunization resulted in significant and specific suppression of anti-TM antibody responses in both IgE and IgG classes. These results provide direct evidence for the potential clinical usefulness of the D-GL immunotherapeutic approach to TMA sensitivity in humans.
UR - http://www.scopus.com/inward/record.url?scp=0018971890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018971890&partnerID=8YFLogxK
M3 - Article
C2 - 6775023
AN - SCOPUS:0018971890
VL - 66
SP - 322
EP - 326
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 4
ER -