Induction of immunologic tolerance to the trimellitate haptenic group in mice: Model for a therapeutic approach to trimellitic anhydride-induced hypersensitivity syndromes in humans?

Fu-Tong Liu, R. F. Bargatze, D. H. Katz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

IgE and IgG antibody responses to the trimellitate (TM) hapten group were elicited in mice by the intraperitoneal injection of the hapten coupled with keyhole limpet hemocyanin (KLH). Treatment of such previously sensitized mice with the same hapten coupled to synthetic copolymer of D-glutamic acid and D-lysine (D-GL) after primary immunization resulted in significant and specific suppression of anti-TM antibody responses in both IgE and IgG classes. These results provide direct evidence for the potential clinical usefulness of the D-GL immunotherapeutic approach to TMA sensitivity in humans.

Original languageEnglish (US)
Pages (from-to)322-326
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume66
Issue number4
StatePublished - 1980

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Haptens
Hypersensitivity
Immunoglobulin E
Antibody Formation
Immunoglobulin G
Intraperitoneal Injections
Lysine
Glutamic Acid
Anti-Idiotypic Antibodies
Immunization
Therapeutics
trimellitic anhydride

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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abstract = "IgE and IgG antibody responses to the trimellitate (TM) hapten group were elicited in mice by the intraperitoneal injection of the hapten coupled with keyhole limpet hemocyanin (KLH). Treatment of such previously sensitized mice with the same hapten coupled to synthetic copolymer of D-glutamic acid and D-lysine (D-GL) after primary immunization resulted in significant and specific suppression of anti-TM antibody responses in both IgE and IgG classes. These results provide direct evidence for the potential clinical usefulness of the D-GL immunotherapeutic approach to TMA sensitivity in humans.",
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AU - Bargatze, R. F.

AU - Katz, D. H.

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