Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat

Jeremy D. Richmon, Kazumasa Fukuda, Frank R Sharp, Linda J. Noble

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume202
Issue number1-2
DOIs
StatePublished - Dec 29 1995
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Heat shock protein
  • Immunocytochemistry
  • Immunoglobulin G
  • Mannitol

ASJC Scopus subject areas

  • Neuroscience(all)

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