Abstract
The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.
Original language | English (US) |
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Pages (from-to) | 1-4 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 202 |
Issue number | 1-2 |
DOIs | |
State | Published - Dec 29 1995 |
Externally published | Yes |
Keywords
- Blood-brain barrier
- Heat shock protein
- Immunocytochemistry
- Immunoglobulin G
- Mannitol
ASJC Scopus subject areas
- Neuroscience(all)