Abstract
The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 202 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Dec 29 1995 |
| Externally published | Yes |
Keywords
- Blood-brain barrier
- Heat shock protein
- Immunocytochemistry
- Immunoglobulin G
- Mannitol
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Richmon, J. D., Fukuda, K., Sharp, F. R., & Noble, L. J. (1995). Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. Neuroscience Letters, 202(1-2), 1-4. https://doi.org/10.1016/0304-3940(95)12208-7