Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat

Jeremy D. Richmon; Kazumasa Fukuda; Frank R Sharp; Linda J. Noble

doi:10.1016/0304-3940(95)12208-7

Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat

Jeremy D. Richmon, Kazumasa Fukuda, Frank R Sharp, Linda J. Noble

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Neuroscience Letters
Volume	202
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(95)12208-7
State	Published - Dec 29 1995
Externally published	Yes

Keywords

Blood-brain barrier
Heat shock protein
Immunocytochemistry
Immunoglobulin G
Mannitol

ASJC Scopus subject areas

Neuroscience(all)

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AU - Richmon, Jeremy D.

AU - Fukuda, Kazumasa

AU - Sharp, Frank R

AU - Noble, Linda J.

PY - 1995/12/29

Y1 - 1995/12/29

N2 - The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.

AB - The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.

KW - Blood-brain barrier

KW - Heat shock protein

KW - Immunocytochemistry

KW - Immunoglobulin G

KW - Mannitol

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ER -

Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat

Abstract

Keywords

ASJC Scopus subject areas

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