Abstract
The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 202 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Dec 29 1995 |
| Externally published | Yes |
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Keywords
- Blood-brain barrier
- Heat shock protein
- Immunocytochemistry
- Immunoglobulin G
- Mannitol
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. / Richmon, Jeremy D.; Fukuda, Kazumasa; Sharp, Frank R; Noble, Linda J.
In: Neuroscience Letters, Vol. 202, No. 1-2, 29.12.1995, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat
AU - Richmon, Jeremy D.
AU - Fukuda, Kazumasa
AU - Sharp, Frank R
AU - Noble, Linda J.
PY - 1995/12/29
Y1 - 1995/12/29
N2 - The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.
AB - The cellular response resulting from breakdown of the blood-brain barrier was evaluated 24 h after hyperosmotic infusion of mannitol into the internal carotid artery in the rat. Heat shock protein (HSP-70), a marker of cellular stress and/or injury, was induced in scattered patches of neurons and glia in regions of barrier breakdown. These findings suggest that osmotically induced breakdown of the blood-brain barrier may result in cell injury.
KW - Blood-brain barrier
KW - Heat shock protein
KW - Immunocytochemistry
KW - Immunoglobulin G
KW - Mannitol
UR - http://www.scopus.com/inward/record.url?scp=0029566972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029566972&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)12208-7
DO - 10.1016/0304-3940(95)12208-7
M3 - Article
C2 - 8787816
AN - SCOPUS:0029566972
VL - 202
SP - 1
EP - 4
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -