Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine

Rimas J. Orentas, James Hildreth, Eugene Obah, Michael Polydefkis, Gale E. Smith, Mary Lou Clements, Robert F. Siliciano

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Abstract

Cytolytic T lymphocyte (CTL) responses were evaluated in humans immunized with recombinant human immunodeficiency virus type 1 (HIV) envelope glycoprotein gp160. Some vaccinees had gp160-specific CTLs that were shown by cloning to be CD4+. Although induced by exogenous antigen, most gp160-specific CTL clones also recognized gp160 synthesized endogenously in target cells. These clones lysed autologous CD4+ T lymphoblasts infected with HIV. Of particular interest were certain vaccine-induced clones that lysed HIV-infected cells, recognized gp160 from diverse HIV isolates, and did not participate in "innocent bystander" killing of noninfected CD4+ T cells that had bound gp120.

Original languageEnglish (US)
Pages (from-to)1234-1237
Number of pages4
JournalScience
Volume248
Issue number4960
StatePublished - Jun 8 1990
Externally publishedYes

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Cite this

Orentas, R. J., Hildreth, J., Obah, E., Polydefkis, M., Smith, G. E., Clements, M. L., & Siliciano, R. F. (1990). Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine. Science, 248(4960), 1234-1237.