Abstract
We show that murine interferons (IFNs)-α/β and -γ induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor cycloheximide (CHX) also stimulates rapid but more stable expression of c-fos mRNA in these cells. Treatment of these cells with a combination of CHX and IFNs results in superinduction of c-fos mRNA. In contrast, IFNs do not affect c-myc mRNA expression in these cells. These results suggest that c-fos gene expression plays a role in signal transduction following binding of IFNs to the receptors
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-112 |
| Number of pages | 8 |
| Journal | Journal of Interferon Research |
| Volume | 8 |
| Issue number | 1 |
| State | Published - 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
Induction of c-fos gene expression by interferons. / Wan, Yu-Jui Yvonne; Levi, B. Z.; Ozato, K.
In: Journal of Interferon Research, Vol. 8, No. 1, 1988, p. 105-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of c-fos gene expression by interferons
AU - Wan, Yu-Jui Yvonne
AU - Levi, B. Z.
AU - Ozato, K.
PY - 1988
Y1 - 1988
N2 - We show that murine interferons (IFNs)-α/β and -γ induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor cycloheximide (CHX) also stimulates rapid but more stable expression of c-fos mRNA in these cells. Treatment of these cells with a combination of CHX and IFNs results in superinduction of c-fos mRNA. In contrast, IFNs do not affect c-myc mRNA expression in these cells. These results suggest that c-fos gene expression plays a role in signal transduction following binding of IFNs to the receptors
AB - We show that murine interferons (IFNs)-α/β and -γ induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor cycloheximide (CHX) also stimulates rapid but more stable expression of c-fos mRNA in these cells. Treatment of these cells with a combination of CHX and IFNs results in superinduction of c-fos mRNA. In contrast, IFNs do not affect c-myc mRNA expression in these cells. These results suggest that c-fos gene expression plays a role in signal transduction following binding of IFNs to the receptors
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UR - http://www.scopus.com/inward/citedby.url?scp=0023866465&partnerID=8YFLogxK
M3 - Article
C2 - 2452846
AN - SCOPUS:0023866465
VL - 8
SP - 105
EP - 112
JO - Journal of Interferon Research
JF - Journal of Interferon Research
SN - 0197-8357
IS - 1
ER -