Induction of c-fos gene expression by interferons

Yu-Jui Yvonne Wan, B. Z. Levi, K. Ozato

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We show that murine interferons (IFNs)-α/β and -γ induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor cycloheximide (CHX) also stimulates rapid but more stable expression of c-fos mRNA in these cells. Treatment of these cells with a combination of CHX and IFNs results in superinduction of c-fos mRNA. In contrast, IFNs do not affect c-myc mRNA expression in these cells. These results suggest that c-fos gene expression plays a role in signal transduction following binding of IFNs to the receptors

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalJournal of Interferon Research
Volume8
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

fos Genes
Interferons
Gene Expression
Messenger RNA
Cycloheximide
Interferon Receptors
Embryonal Carcinoma Stem Cells
NIH 3T3 Cells
Protein Synthesis Inhibitors
Signal Transduction
Cell Culture Techniques

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Induction of c-fos gene expression by interferons. / Wan, Yu-Jui Yvonne; Levi, B. Z.; Ozato, K.

In: Journal of Interferon Research, Vol. 8, No. 1, 1988, p. 105-112.

Research output: Contribution to journalArticle

Wan, Y-JY, Levi, BZ & Ozato, K 1988, 'Induction of c-fos gene expression by interferons', Journal of Interferon Research, vol. 8, no. 1, pp. 105-112.
Wan, Yu-Jui Yvonne ; Levi, B. Z. ; Ozato, K. / Induction of c-fos gene expression by interferons. In: Journal of Interferon Research. 1988 ; Vol. 8, No. 1. pp. 105-112.
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