Induction of c-fos gene expression by interferons

Yu-Jui Yvonne Wan, B. Z. Levi, K. Ozato

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We show that murine interferons (IFNs)-α/β and -γ induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor cycloheximide (CHX) also stimulates rapid but more stable expression of c-fos mRNA in these cells. Treatment of these cells with a combination of CHX and IFNs results in superinduction of c-fos mRNA. In contrast, IFNs do not affect c-myc mRNA expression in these cells. These results suggest that c-fos gene expression plays a role in signal transduction following binding of IFNs to the receptors

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalJournal of Interferon Research
Volume8
Issue number1
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology

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