Abstract
We show that murine interferons (IFNs)-α/β and -γ induce expression of the protooncogene c-fos in F9 embryonal carcinoma cells, NIH-3T3 cells, and other tissue culture cells. The induction of c-fos mRNA is rapid and transient in that the mRNA appears within 15 min and disappears by 2 h following IFN treatment. The protein synthesis inhibitor cycloheximide (CHX) also stimulates rapid but more stable expression of c-fos mRNA in these cells. Treatment of these cells with a combination of CHX and IFNs results in superinduction of c-fos mRNA. In contrast, IFNs do not affect c-myc mRNA expression in these cells. These results suggest that c-fos gene expression plays a role in signal transduction following binding of IFNs to the receptors
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-112 |
| Number of pages | 8 |
| Journal | Journal of Interferon Research |
| Volume | 8 |
| Issue number | 1 |
| State | Published - 1988 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Virology
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Cite this
Wan, Y-J. Y., Levi, B. Z., & Ozato, K. (1988). Induction of c-fos gene expression by interferons. Journal of Interferon Research, 8(1), 105-112.