Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques

Ali Azizi, David E. Anderson, Jose V Torres, Andrei Ogrel, Masoud Ghorbani, Catalina Soare, Paul Sandstrom, Jocelyne Fournier, Francisco Diaz-Mitoma

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29 Scopus citations

Abstract

One of the major obstacles in the design of an effective vaccine against HIV-1 is its antigenic variation, which results in viral escape from the immune system. Through a bioinformatics approach, we developed an innovative multivalent HIV-1 vaccine comprised of a pool of 176 lipidated and nonlipidated peptides representing variable regions of Env and Gag proteins. The potency and breadth of the candidate vaccine against a panel of HIV-1 subtypes was evaluated in nonhuman primate (cynomolgus macaques) and humanized mouse (HLA-A2.1) models. The results demonstrate strong immunogenicity with both breadth (humoral and cellular immunity) and depth (immune recognition of widely divergent viral sequences) against heterologous HIV-1 subtypes A-F.

Original languageEnglish (US)
Pages (from-to)2174-2186
Number of pages13
JournalJournal of Immunology
Volume180
Issue number4
StatePublished - Feb 15 2008

ASJC Scopus subject areas

  • Immunology

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