Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques

Ali Azizi, David E. Anderson, Jose V Torres, Andrei Ogrel, Masoud Ghorbani, Catalina Soare, Paul Sandstrom, Jocelyne Fournier, Francisco Diaz-Mitoma

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

One of the major obstacles in the design of an effective vaccine against HIV-1 is its antigenic variation, which results in viral escape from the immune system. Through a bioinformatics approach, we developed an innovative multivalent HIV-1 vaccine comprised of a pool of 176 lipidated and nonlipidated peptides representing variable regions of Env and Gag proteins. The potency and breadth of the candidate vaccine against a panel of HIV-1 subtypes was evaluated in nonhuman primate (cynomolgus macaques) and humanized mouse (HLA-A2.1) models. The results demonstrate strong immunogenicity with both breadth (humoral and cellular immunity) and depth (immune recognition of widely divergent viral sequences) against heterologous HIV-1 subtypes A-F.

Original languageEnglish (US)
Pages (from-to)2174-2186
Number of pages13
JournalJournal of Immunology
Volume180
Issue number4
StatePublished - Feb 15 2008

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Subunit Vaccines
Macaca
HIV-1
Vaccines
env Gene Products
gag Gene Products
Antigenic Variation
AIDS Vaccines
Humoral Immunity
Computational Biology
Cellular Immunity
Primates
Immune System
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

Azizi, A., Anderson, D. E., Torres, J. V., Ogrel, A., Ghorbani, M., Soare, C., ... Diaz-Mitoma, F. (2008). Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques. Journal of Immunology, 180(4), 2174-2186.

Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques. / Azizi, Ali; Anderson, David E.; Torres, Jose V; Ogrel, Andrei; Ghorbani, Masoud; Soare, Catalina; Sandstrom, Paul; Fournier, Jocelyne; Diaz-Mitoma, Francisco.

In: Journal of Immunology, Vol. 180, No. 4, 15.02.2008, p. 2174-2186.

Research output: Contribution to journalArticle

Azizi, A, Anderson, DE, Torres, JV, Ogrel, A, Ghorbani, M, Soare, C, Sandstrom, P, Fournier, J & Diaz-Mitoma, F 2008, 'Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques', Journal of Immunology, vol. 180, no. 4, pp. 2174-2186.
Azizi, Ali ; Anderson, David E. ; Torres, Jose V ; Ogrel, Andrei ; Ghorbani, Masoud ; Soare, Catalina ; Sandstrom, Paul ; Fournier, Jocelyne ; Diaz-Mitoma, Francisco. / Induction of broad cross-subtype-specific HIV-1 immune responses by a novel multivalent HIV-1 peptide vaccine in cynomolgus macaques. In: Journal of Immunology. 2008 ; Vol. 180, No. 4. pp. 2174-2186.
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