Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

Harry Kestler, Toshiaki Kodama, Douglas Ringler, Marta Marthas, Niels C Pedersen, Andrew Lackner, Dean Regier, Prabhat Sehgal, Muthiah Daniel, Norval King, Ronald Desrosiers

Research output: Contribution to journalArticle

448 Citations (Scopus)

Abstract

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.

Original languageEnglish (US)
Pages (from-to)1109-1112
Number of pages4
JournalScience
Volume248
Issue number4959
StatePublished - 1990

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Simian Immunodeficiency Virus
Macaca mulatta
Acquired Immunodeficiency Syndrome
Dissection
Vaccines
Animal Models
Clone Cells
Viruses
Research

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N. C., Lackner, A., ... Desrosiers, R. (1990). Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science, 248(4959), 1109-1112.

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. / Kestler, Harry; Kodama, Toshiaki; Ringler, Douglas; Marthas, Marta; Pedersen, Niels C; Lackner, Andrew; Regier, Dean; Sehgal, Prabhat; Daniel, Muthiah; King, Norval; Desrosiers, Ronald.

In: Science, Vol. 248, No. 4959, 1990, p. 1109-1112.

Research output: Contribution to journalArticle

Kestler, H, Kodama, T, Ringler, D, Marthas, M, Pedersen, NC, Lackner, A, Regier, D, Sehgal, P, Daniel, M, King, N & Desrosiers, R 1990, 'Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus', Science, vol. 248, no. 4959, pp. 1109-1112.
Kestler, Harry ; Kodama, Toshiaki ; Ringler, Douglas ; Marthas, Marta ; Pedersen, Niels C ; Lackner, Andrew ; Regier, Dean ; Sehgal, Prabhat ; Daniel, Muthiah ; King, Norval ; Desrosiers, Ronald. / Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. In: Science. 1990 ; Vol. 248, No. 4959. pp. 1109-1112.
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