Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

Harry Kestler, Toshiaki Kodama, Douglas Ringler, Marta Marthas, Niels C Pedersen, Andrew Lackner, Dean Regier, Prabhat Sehgal, Muthiah Daniel, Norval King, Ronald Desrosiers

Research output: Contribution to journalArticle

459 Scopus citations

Abstract

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.

Original languageEnglish (US)
Pages (from-to)1109-1112
Number of pages4
JournalScience
Volume248
Issue number4959
StatePublished - 1990

ASJC Scopus subject areas

  • Medicine(all)
  • General

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    Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N. C., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N., & Desrosiers, R. (1990). Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science, 248(4959), 1109-1112.