Induction and effector phase of allergic lung inflammation is independent of 0121/0119 and LT-beta

Corinne Ploix, Riaz I. Zuberi, Fu-Tong Liu, Monica J. Carson, David D. Lo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The chemokines CCL2I and CCLI9, and cell bound TNF family ligand lymphotoxin beta (LTβ), have been associated with numerous chronic inflammatory diseases. A general role in chronic inflammatory diseases cannot be assumed however; in the case of allergic inflammatory disease, CCL21/CCL19 and LTβ have not been associated with the induction, recruitment, or effector function of Th2 cells nor dendritic cells to the lung. We have examined the induction of allergic inflammatory lung disease in mice deficient in CCL21/CCL19 or LTβ and found that both kinds of mice can develop allergic lung inflammation. To control for effects of priming differences in knockout mice, adoptive transfers of Th2 cells were also performed, and they showed that such effector cells had equivalent effects on airway hy per-responsiveness in both knockout background recipients. Moreover, class II positive antigen presenting cells (B cells and CDIIc+ dendritic cells) showed normal recruitment to the peribronchial spaces along with CD4 T cells. Thus, the induction of allergic responses and recruitment of both effector Th2 cells and antigen presenting cells to lung peribronchial spaces can develop independently of CCL21/CCL19 and LTβ.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalInternational Journal of Medical Sciences
Volume6
Issue number2
StatePublished - Feb 26 2009

Fingerprint

Lymphotoxin-beta
Th2 Cells
Pneumonia
Antigen-Presenting Cells
Dendritic Cells
Chronic Disease
Lung
Adoptive Transfer
Histocompatibility Antigens Class II
Chemokines
Knockout Mice
Lung Diseases
B-Lymphocytes
Ligands
T-Lymphocytes

Keywords

  • Asthma
  • Chemokine
  • Dendritic cell
  • Th2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Induction and effector phase of allergic lung inflammation is independent of 0121/0119 and LT-beta. / Ploix, Corinne; Zuberi, Riaz I.; Liu, Fu-Tong; Carson, Monica J.; Lo, David D.

In: International Journal of Medical Sciences, Vol. 6, No. 2, 26.02.2009, p. 85-92.

Research output: Contribution to journalArticle

Ploix, Corinne ; Zuberi, Riaz I. ; Liu, Fu-Tong ; Carson, Monica J. ; Lo, David D. / Induction and effector phase of allergic lung inflammation is independent of 0121/0119 and LT-beta. In: International Journal of Medical Sciences. 2009 ; Vol. 6, No. 2. pp. 85-92.
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