Abstract
Cardiac ion channel mutations can lead to alterations of action potential and/or conduction properties, and consequently, arrhythmias. Although sudden cardiac death is a common manifestation of inherited arrhythmias, many aspects of the underlying mechanisms remain undefined. In addition to their potential for cell-based therapies, patient-specific induced pluripotent stem cells (iPSCs) also offer an expandable source of human cardiomyocytes for disease modeling, high-throughput drug screening and cardiotoxicity testing. Here, we review current efforts of using iPSC to model monogenetic arrhythmic diseases and discuss the associated challenges.
| Original language | English (US) |
|---|---|
| Journal | Drug Discovery Today: Disease Models |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2012 |
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ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine
Cite this
Induced pluripotent stem cells as a disease model for studying inherited arrhythmias : Promises and hurdles. / Lui, Kathy O.; Stachel, Maxine W.; Lieu, Deborah; Li, Ronald A.; Bu, Lei.
In: Drug Discovery Today: Disease Models, Vol. 9, No. 4, 12.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induced pluripotent stem cells as a disease model for studying inherited arrhythmias
T2 - Promises and hurdles
AU - Lui, Kathy O.
AU - Stachel, Maxine W.
AU - Lieu, Deborah
AU - Li, Ronald A.
AU - Bu, Lei
PY - 2012/12
Y1 - 2012/12
N2 - Cardiac ion channel mutations can lead to alterations of action potential and/or conduction properties, and consequently, arrhythmias. Although sudden cardiac death is a common manifestation of inherited arrhythmias, many aspects of the underlying mechanisms remain undefined. In addition to their potential for cell-based therapies, patient-specific induced pluripotent stem cells (iPSCs) also offer an expandable source of human cardiomyocytes for disease modeling, high-throughput drug screening and cardiotoxicity testing. Here, we review current efforts of using iPSC to model monogenetic arrhythmic diseases and discuss the associated challenges.
AB - Cardiac ion channel mutations can lead to alterations of action potential and/or conduction properties, and consequently, arrhythmias. Although sudden cardiac death is a common manifestation of inherited arrhythmias, many aspects of the underlying mechanisms remain undefined. In addition to their potential for cell-based therapies, patient-specific induced pluripotent stem cells (iPSCs) also offer an expandable source of human cardiomyocytes for disease modeling, high-throughput drug screening and cardiotoxicity testing. Here, we review current efforts of using iPSC to model monogenetic arrhythmic diseases and discuss the associated challenges.
UR - http://www.scopus.com/inward/record.url?scp=84876694169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876694169&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2012.09.001
DO - 10.1016/j.ddmod.2012.09.001
M3 - Article
VL - 9
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
SN - 1740-6757
IS - 4
ER -