Indolent cutaneous T-cell lymphoma presenting as cutaneous lymphocytosis in dogs

Verena K Affolter, Thelma Lee Gross, Peter F Moore

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Cutaneous lymphoproliferative diseases encompass a spectrum of lesions, ranging from self-limiting, reactive infiltrates to high-grade lymphomas. In humans, cutaneous lymphocytosis (CL) refers to self-limiting or slowly progressive monomorphic lymphocytic infiltrates of mostly unknown cause. It morphologically mimics cutaneous lymphoma. CL in cats also is a slowly progressive disease. Immunophenotyping and clonality testing of feline CL support an indolent lymphoma for the majority of cases studied. This study reports CL in dogs. Erythematous, scaly and alopecic macules, patches or plaques were present in eight dogs. Breed predilection was not observed; six of eight dogs were females; and ages ranged from 5 to 14 years. Diffuse monomorphic non-epitheliotropic infiltrates of CD3+ (eight of eight), CD45 - (four of eight) or CD45+/- (four of eight) and CD45RA- (seven of eight) T lymphocytes were present in the superficial and mid-dermis. Further immunophenotyping of five cases revealed TCR-γδ+ T cells (one of five) or TCR- αβ+ (four of five) T cells. TCR-αβ+ populations were either CD8+ (two of four) or CD4-CD8 - (2/4). Clonality testing found clonal (seven of eight) or pseudoclonal (one of eight) rearrangement of the TCR-gamma locus of the lesional T cells. Prednisone, prednisolone and methylprednisolone acetate were the most commonly administered drugs. The lesions remained stable for long periods up to 6 years. Five dogs were euthanized due to progression of the skin lesions (three of five), peripheral lymphadenopathy of unknown origin (one of five) or high-grade lymphoma (one of five). One dog was lost for follow-up and two dogs are still alive (17 and 9 months after diagnosis). Canine CL is best considered an initially indolent lymphoma, with slow progression and a potential for progression to high-grade lymphoma.

Original languageEnglish (US)
Pages (from-to)577-585
Number of pages9
JournalVeterinary Dermatology
Volume20
Issue number5-6
DOIs
StatePublished - Oct 2009

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Cutaneous T-Cell Lymphoma
Lymphocytosis
lymphoma
T-lymphocytes
Dogs
Skin
dogs
Non-Hodgkin's Lymphoma
T-Lymphocytes
Immunophenotyping
Lymphoma
lesions (animal)
cats
prednisone
lymphatic diseases
prednisolone
dermis
Felidae
skin lesions
Dermis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Indolent cutaneous T-cell lymphoma presenting as cutaneous lymphocytosis in dogs. / Affolter, Verena K; Gross, Thelma Lee; Moore, Peter F.

In: Veterinary Dermatology, Vol. 20, No. 5-6, 10.2009, p. 577-585.

Research output: Contribution to journalArticle

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