Individual differences in the functional neuroanatomy of inhibitory control

Hugh Garavan, Robert Hester, Kevin Murphy, Catherine Fassbender, Clare Kelly

Research output: Contribution to journalArticlepeer-review

202 Scopus citations


We combined the data of five event-related fMRI studies of response inhibition. The re-analysis (n = 71) revealed response inhibition to be accomplished by a largely right hemisphere network of prefrontal, parietal, subcortical and midline regions, with converging evidence pointing to the particular importance of the right frontal operculum. Functional differences were observed between the sexes with greater activity in females in many of these cortical regions. Despite the relatively narrow age range (18-46), cortical activity, on the whole, tended to increase with age, echoing a pattern of functional recruitment often observed in the elderly. More absentminded subjects showed greater activity in fronto-parietal areas, while speed of Go trial responses produced a varied pattern of activation differences in more posterior and subcortical areas. Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network.

Original languageEnglish (US)
Pages (from-to)130-142
Number of pages13
JournalBrain Research
Issue number1
StatePublished - Aug 11 2006
Externally publishedYes


  • Cognitive Control
  • Individual Differences
  • Inhibition

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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