Individual differences in the cognitive and neurobiological consequences of normal aging

Peter R. Rapp, David G Amaral

Research output: Contribution to journalArticle

237 Scopus citations


Defining the neural basis of age-related cognitive dysfunction is a major goal of current research on aging. Compelling evidence from laboratory animals and humans indicates that aging does not inevitably lead to cognitive decline. Conducting neurobiological investigations in subjects that have previously undergone behavioral characterization has therefore emerged as a promising strategy for identifying those alterations in brain structure and function that are specifically associated with age-related cognitive impairment.

Original languageEnglish (US)
Pages (from-to)340-345
Number of pages6
JournalTrends in Neurosciences
Issue number9
StatePublished - 1992
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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