Individual differences in sugar consumption predict amphetamine-induced dopamine overflow in nucleus accumbens

Terrence L. Sills, Jacqueline Crawley

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Rats exhibit individual differences in their consumption of sugar and in their response to amphetamine treatments. Intrinsic variation in the functiohing of the mesolimbic dopamine system is one potential mechanism underlying the expression of these individual differences. The present experiment examined the relationship between sugar consumption and the dopaminergic response to amphetamine. In vivo microdialysis was used to assess amphetamine-stimulated dopamine overflow in the posterior-medial nucleus accumbens in LOW and HIGH sugar feeders. Sugar consumption correlated significantly with amphetamine-stimulated accumbens-dopamine overflow. HIGH rats exhibited significantly higher levels of amphetamine-stimulated accumbens-dopamine overflow than LOW rats. These results suggest that the propensity to ingest sugar is a predictor of the nucleus accumbens dopaminergic response to amphetamine treatment.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalEuropean Journal of Pharmacology
Volume303
Issue number3
DOIs
StatePublished - May 15 1996
Externally publishedYes

Keywords

  • amphetamine
  • dopamine
  • individual difference
  • microdialysis
  • nucleus accumbens
  • rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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