Individual differences in GABA content are reliable but are not uniform across the human cortex

Ian Greenhouse, Sean Noah, Richard J Maddock, Richard B. Ivry

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

1H magnetic resonance spectroscopy (MRS) provides a powerful tool to measure gamma-aminobutyric acid (GABA), the principle inhibitory neurotransmitter in the human brain. We asked whether individual differences in MRS estimates of GABA are uniform across the cortex or vary between regions. In two sessions, resting GABA concentrations in the lateral prefrontal, sensorimotor, dorsal premotor, and occipital cortices were measured in twenty-eight healthy individuals. GABA estimates within each region were stable across weeks, with low coefficients of variation. Despite this stability, the GABA estimates were not correlated between regions. In contrast, the percentage of brain tissue per volume, a control measure, was correlated between the three anterior regions. These results provide an interesting dissociation between an anatomical measure of individual differences and a neurochemical measure. The different patterns of anatomy and GABA concentrations have implications for understanding regional variation in the molecular topography of the brain in health and disease.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNeuroImage
Volume139
DOIs
StatePublished - Oct 1 2016

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Individuality
gamma-Aminobutyric Acid
Brain
Magnetic Resonance Spectroscopy
Occipital Lobe
Motor Cortex
Neurotransmitter Agents
Anatomy
Health

Keywords

  • Cortex
  • GABA
  • Individual differences
  • Inhibition
  • Magnetic resonance spectroscopy
  • Molecular topography

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Individual differences in GABA content are reliable but are not uniform across the human cortex. / Greenhouse, Ian; Noah, Sean; Maddock, Richard J; Ivry, Richard B.

In: NeuroImage, Vol. 139, 01.10.2016, p. 1-7.

Research output: Contribution to journalArticle

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