Indium-111-labeled autologous platelets for location of vascular thrombi in humans

D. A. Goodwin, J. T. Bushberg, P. W. Doherty, M. J. Lipton, F. K. Conley, C. I. Diamanti, C. F. Meares

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Abstract

Twenty-two patients suspected of having either venous or arterial thrombi were studied with In-111-labeled autologous platelets. Whole-body scans were performed 3, 24, and 48 hr following i.v. injection. Twelve patients studied with saline-washed platelets had unsatisfactory 15-min recovery and biologic half-time. When the labeling was carried out in plasma, these values compared favorably with normal values reported for Cr-51-labeled autologous platelets. Of ten patients studied using platelets labeled in plasma, three had normal scans, six had abnormal scans, and one had an equivocal scan. All six abnormal scans were confirmed with corresponding positive findings in either the venogram, arteriogram, or lung scan.

Original languageEnglish (US)
Pages (from-to)626-634
Number of pages9
JournalJournal of Nuclear Medicine
Volume19
Issue number6
StatePublished - 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Goodwin, D. A., Bushberg, J. T., Doherty, P. W., Lipton, M. J., Conley, F. K., Diamanti, C. I., & Meares, C. F. (1978). Indium-111-labeled autologous platelets for location of vascular thrombi in humans. Journal of Nuclear Medicine, 19(6), 626-634.