Indirect computed tomography lymphography of subdiaphragmatic lymph nodes using iodinated nanoparticles in normal dogs

Erik R Wisner, Richard W Katzberg, Philip D. Koblik, John P McGahan, Stephen M Griffey, Christiana M. Drake, Philip P. Harnish, Adele R. Vessey, Patrick J. Haley

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Rationale and Objectives.: We evaluated the imaging characteristics of an iodinated particulate contrast agent for indirect computed tomography (CT) lymphography of normal subdiaphragmatic lymph nodes in dogs. Methods.: Four milliliters of a 15% (wt/vol) iodinated nanoparticle suspension was injected into the gastric, colonic, rectal, or cervical submucosa, loose paraprostatic fascia, or metatarsal subcutaneous tissues in 10 healthy beagles. Endoscopic, CT, or ultrasound guidance was used when necessary to facilitate contrast agent delivery. CT and radiographic images were obtained prior to contrast administration and at 4 hr, 24 hr, and 7 days postcontrast injection. Postmortem examinations were then conducted. Results.: CT images showed enhancement of regional lymph nodes draining the various injection sites. The mean attenuation of opacified nodes was 678 ± 463 Hounsfield units 24 hr after injection and remained elevated 7 days later. Lymph node opacification on CT images correlated well with the node location observed on postmortem examinations. Conclusion.: Subdiaphragmatic lymph nodes can be effectively opacified using an iodinated nanoparticle contrast agent for indirect CT lymphography.

Original languageEnglish (US)
Pages (from-to)405-412
Number of pages8
JournalAcademic Radiology
Volume2
Issue number5
DOIs
StatePublished - 1995

Keywords

  • Computed tomography (CT)
  • contrast media
  • indirect lymphography
  • iodinated nanoparticles
  • lymphangiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Indirect computed tomography lymphography of subdiaphragmatic lymph nodes using iodinated nanoparticles in normal dogs'. Together they form a unique fingerprint.

  • Cite this