Indication for pediatric muscle biopsy determines usefulness

Ramin Jamshidi, Michael R. Harrison, Hanmin Lee, Kerilyn K. Nobuhara, Diana L Farmer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: Diagnostic skeletal muscle biopsy is an invasive procedure used for evaluation of neuromuscular disorders. We hypothesize that the yield of biopsy varies with its indication or suspected diagnosis. Methods: Retrospective review of all muscle biopsies was performed at an academic tertiary care center between January 1, 1996, and August 1, 2006. Results: A total of 142 muscle biopsies were performed on 127 children. Mean age at biopsy was 5.3 years (median, 3.3; range, 8 days-21 years) with 48% female. Follow-up was maintained for a mean 3.4 years (median, 2.2; range, 1 month-10.4 years). Specific pathological diagnoses were obtained from 33 (23%) of 142. Changes in therapy resulted from 11 (8%) of 142 biopsies. Treatment changed for all patients with prebiopsy suspicion of inflammatory or neoplastic processes (7/7, 100%); these accounted for 7 (64%) of 11 patients with treatment changes. Thirteen patients underwent multiple biopsies, with 1 (8%) patient's treatment adjusted as a result. Fifteen neonates (<100 days) underwent a total of 17 biopsies; none changed treatment plans. Conclusions: Muscle biopsy for neuromuscular disorders is inconsistently useful. Specific diagnoses are occasionally revealed, but treatment changes are infrequent except in those patients with suspected neoplastic or inflammatory disease. Ongoing study is required to determine the most rational indications for this procedure.

Original languageEnglish (US)
Pages (from-to)2199-2201
Number of pages3
JournalJournal of Pediatric Surgery
Volume43
Issue number12
DOIs
StatePublished - Dec 2008

Fingerprint

Pediatrics
Biopsy
Muscles
Therapeutics
Neoplastic Processes
Tertiary Care Centers
Skeletal Muscle
Newborn Infant

Keywords

  • Dystrophy
  • Mitochondria
  • Muscle biopsy
  • Myopathy
  • Neuromuscular
  • Pediatric

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Indication for pediatric muscle biopsy determines usefulness. / Jamshidi, Ramin; Harrison, Michael R.; Lee, Hanmin; Nobuhara, Kerilyn K.; Farmer, Diana L.

In: Journal of Pediatric Surgery, Vol. 43, No. 12, 12.2008, p. 2199-2201.

Research output: Contribution to journalArticle

Jamshidi, Ramin ; Harrison, Michael R. ; Lee, Hanmin ; Nobuhara, Kerilyn K. ; Farmer, Diana L. / Indication for pediatric muscle biopsy determines usefulness. In: Journal of Pediatric Surgery. 2008 ; Vol. 43, No. 12. pp. 2199-2201.
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