Abstract
Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage vaccines could be increased by: (1) PDT of the priming tumor cells, and (2) injection of allogeneic glioma cells directly into brain tumors. Experiments were conducted in an in vivo brain tumor model using Fisher rats and BT4C (allogeneic) and F98 (syngeneic) glioma cells. Preliminary results showed that vaccination alone had significantly less inhibitory effect on F98 tumor growth compared to the combination of vaccination and allogeneic cell (BT4C) injection.
| Original language | English (US) |
|---|---|
| Title of host publication | Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation |
| Publisher | SPIE |
| Volume | 9690 |
| ISBN (Electronic) | 9781628419603 |
| DOIs | |
| State | Published - 2016 |
| Event | Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation - San Francisco, United States Duration: Feb 13 2016 → Feb 16 2016 |
Other
| Other | Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/13/16 → 2/16/16 |
Fingerprint
Keywords
- brain tumor
- BT4C
- F98
- glioma vaccine
- immunotherapy
- macrophages
- photodynamic therapy
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells. / Christie, Catherine E.; Peng, Qian; Madsen, Steen J.; Uzal, Francisco A; Hirschberg, Henry.
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation. Vol. 9690 SPIE, 2016. 96900D.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells
AU - Christie, Catherine E.
AU - Peng, Qian
AU - Madsen, Steen J.
AU - Uzal, Francisco A
AU - Hirschberg, Henry
PY - 2016
Y1 - 2016
N2 - Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage vaccines could be increased by: (1) PDT of the priming tumor cells, and (2) injection of allogeneic glioma cells directly into brain tumors. Experiments were conducted in an in vivo brain tumor model using Fisher rats and BT4C (allogeneic) and F98 (syngeneic) glioma cells. Preliminary results showed that vaccination alone had significantly less inhibitory effect on F98 tumor growth compared to the combination of vaccination and allogeneic cell (BT4C) injection.
AB - Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage vaccines could be increased by: (1) PDT of the priming tumor cells, and (2) injection of allogeneic glioma cells directly into brain tumors. Experiments were conducted in an in vivo brain tumor model using Fisher rats and BT4C (allogeneic) and F98 (syngeneic) glioma cells. Preliminary results showed that vaccination alone had significantly less inhibitory effect on F98 tumor growth compared to the combination of vaccination and allogeneic cell (BT4C) injection.
KW - brain tumor
KW - BT4C
KW - F98
KW - glioma vaccine
KW - immunotherapy
KW - macrophages
KW - photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=84978664202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978664202&partnerID=8YFLogxK
U2 - 10.1117/12.2213569
DO - 10.1117/12.2213569
M3 - Conference contribution
AN - SCOPUS:84978664202
VL - 9690
BT - Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
PB - SPIE
ER -