Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells

Catherine E. Christie, Qian Peng, Steen J. Madsen, Francisco A Uzal, Henry Hirschberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage vaccines could be increased by: (1) PDT of the priming tumor cells, and (2) injection of allogeneic glioma cells directly into brain tumors. Experiments were conducted in an in vivo brain tumor model using Fisher rats and BT4C (allogeneic) and F98 (syngeneic) glioma cells. Preliminary results showed that vaccination alone had significantly less inhibitory effect on F98 tumor growth compared to the combination of vaccination and allogeneic cell (BT4C) injection.

Original languageEnglish (US)
Title of host publicationClinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
PublisherSPIE
Volume9690
ISBN (Electronic)9781628419603
DOIs
StatePublished - 2016
EventClinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation - San Francisco, United States
Duration: Feb 13 2016Feb 16 2016

Other

OtherClinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation
CountryUnited States
CitySan Francisco
Period2/13/162/16/16

Keywords

  • brain tumor
  • BT4C
  • F98
  • glioma vaccine
  • immunotherapy
  • macrophages
  • photodynamic therapy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Christie, C. E., Peng, Q., Madsen, S. J., Uzal, F. A., & Hirschberg, H. (2016). Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells. In Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation (Vol. 9690). [96900D] SPIE. https://doi.org/10.1117/12.2213569