Increasing dispensable amino acids in diets of kittens fed essential amino acids at or below their requirement increases the requirement for arginine

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6 Citations (Scopus)

Abstract

Kittens fed diets containing 0.75 x the NRC (1986) essential amino acid requirement (EAArq) and 210 to 560 g crude protein (CP)/kg diet exhibited, with increasing CP: 1) decreasing weight gain, 2) decreasing plasma arginine concentrations, 3) increasing urinary erotic acid excretion, 4) increasing plasma glutamic acid concentrations, and 5) plasma isoleucine concentrations at levels that suggest a marginal isoleucine deficiency. Kittens fed a control diet (CD) containing 1.5 x EAArq and 350 g CP/kg diet had maximal weight gains and no orotic aciduria. It was concluded that the decreased weight gain and adverse metabolic effects were caused by arginine deficiency and possibly glutamic acid toxicity induced by high dietary dispensable amino acids. Kittens fed the diets containing 1.0 x EAArq and 350 and 560 g CP/kg diet had depressed plasma arginine and elevated glutamic acid concentrations and orotic aciduria. These results indicate that 10 g arg/kg diet is not adequate at CP concentrations above 280 g/kg and the calculated requirement of arginine is (0.02 g arginine/g CP) x (Y g CP/kg diet) + (4.0 g arginine/kg diet) where Y is the dietary CP level.

Original languageEnglish (US)
Pages (from-to)257-272
Number of pages16
JournalAmino Acids
Volume13
Issue number3-4
DOIs
StatePublished - 1997

Fingerprint

Essential Amino Acids
Nutrition
Arginine
Diet
Amino Acids
Proteins
Weight Gain
Plasmas
Glutamic Acid
Isoleucine
Dietary Proteins
Toxicity
Acids

Keywords

  • Crude protein
  • Dispensable amino acids
  • Essential amino acids
  • Feline
  • Orotic acid

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

Cite this

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title = "Increasing dispensable amino acids in diets of kittens fed essential amino acids at or below their requirement increases the requirement for arginine",
abstract = "Kittens fed diets containing 0.75 x the NRC (1986) essential amino acid requirement (EAArq) and 210 to 560 g crude protein (CP)/kg diet exhibited, with increasing CP: 1) decreasing weight gain, 2) decreasing plasma arginine concentrations, 3) increasing urinary erotic acid excretion, 4) increasing plasma glutamic acid concentrations, and 5) plasma isoleucine concentrations at levels that suggest a marginal isoleucine deficiency. Kittens fed a control diet (CD) containing 1.5 x EAArq and 350 g CP/kg diet had maximal weight gains and no orotic aciduria. It was concluded that the decreased weight gain and adverse metabolic effects were caused by arginine deficiency and possibly glutamic acid toxicity induced by high dietary dispensable amino acids. Kittens fed the diets containing 1.0 x EAArq and 350 and 560 g CP/kg diet had depressed plasma arginine and elevated glutamic acid concentrations and orotic aciduria. These results indicate that 10 g arg/kg diet is not adequate at CP concentrations above 280 g/kg and the calculated requirement of arginine is (0.02 g arginine/g CP) x (Y g CP/kg diet) + (4.0 g arginine/kg diet) where Y is the dietary CP level.",
keywords = "Crude protein, Dispensable amino acids, Essential amino acids, Feline, Orotic acid",
author = "Taylor, {T. P.} and James Morris and Kass, {Philip H} and Quinton Rogers",
year = "1997",
doi = "10.1007/BF01372591",
language = "English (US)",
volume = "13",
pages = "257--272",
journal = "Amino Acids",
issn = "0939-4451",
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T1 - Increasing dispensable amino acids in diets of kittens fed essential amino acids at or below their requirement increases the requirement for arginine

AU - Taylor, T. P.

AU - Morris, James

AU - Kass, Philip H

AU - Rogers, Quinton

PY - 1997

Y1 - 1997

N2 - Kittens fed diets containing 0.75 x the NRC (1986) essential amino acid requirement (EAArq) and 210 to 560 g crude protein (CP)/kg diet exhibited, with increasing CP: 1) decreasing weight gain, 2) decreasing plasma arginine concentrations, 3) increasing urinary erotic acid excretion, 4) increasing plasma glutamic acid concentrations, and 5) plasma isoleucine concentrations at levels that suggest a marginal isoleucine deficiency. Kittens fed a control diet (CD) containing 1.5 x EAArq and 350 g CP/kg diet had maximal weight gains and no orotic aciduria. It was concluded that the decreased weight gain and adverse metabolic effects were caused by arginine deficiency and possibly glutamic acid toxicity induced by high dietary dispensable amino acids. Kittens fed the diets containing 1.0 x EAArq and 350 and 560 g CP/kg diet had depressed plasma arginine and elevated glutamic acid concentrations and orotic aciduria. These results indicate that 10 g arg/kg diet is not adequate at CP concentrations above 280 g/kg and the calculated requirement of arginine is (0.02 g arginine/g CP) x (Y g CP/kg diet) + (4.0 g arginine/kg diet) where Y is the dietary CP level.

AB - Kittens fed diets containing 0.75 x the NRC (1986) essential amino acid requirement (EAArq) and 210 to 560 g crude protein (CP)/kg diet exhibited, with increasing CP: 1) decreasing weight gain, 2) decreasing plasma arginine concentrations, 3) increasing urinary erotic acid excretion, 4) increasing plasma glutamic acid concentrations, and 5) plasma isoleucine concentrations at levels that suggest a marginal isoleucine deficiency. Kittens fed a control diet (CD) containing 1.5 x EAArq and 350 g CP/kg diet had maximal weight gains and no orotic aciduria. It was concluded that the decreased weight gain and adverse metabolic effects were caused by arginine deficiency and possibly glutamic acid toxicity induced by high dietary dispensable amino acids. Kittens fed the diets containing 1.0 x EAArq and 350 and 560 g CP/kg diet had depressed plasma arginine and elevated glutamic acid concentrations and orotic aciduria. These results indicate that 10 g arg/kg diet is not adequate at CP concentrations above 280 g/kg and the calculated requirement of arginine is (0.02 g arginine/g CP) x (Y g CP/kg diet) + (4.0 g arginine/kg diet) where Y is the dietary CP level.

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KW - Essential amino acids

KW - Feline

KW - Orotic acid

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