Abstract
We demonstrate both theoretically and experimentally that ultrasound radiation force can significantly increase the binding efficiency of targeted contrast agents, without increasing nonspecific adhesion of agents to the target surface. The radial oscillation of a microbubble was determined using a previously developed model, and then displacement and translational velocity were predicted by solving the trajectory equation of the microbubble. Theoretical evaluation showed that a microbubble can be easily displaced across a vessel by radiation force. Experiments with an avidin-coated tube and biotin-targeted microbubbles clearly demonstrated the effect of radiation force in increasing the efficiency of specific binding. Under control conditions, only sporadic binding to the vessel wall was observed. With radiation force, targeted agents adhered to the vessel wall at 20 times the rate of control experiments. An experiment with microbubbles targeted to α vβ 3expressing cells showed similar results.
Original language | English (US) |
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Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
Editors | M.P. Yuhas |
Pages | 1114-1117 |
Number of pages | 4 |
Volume | 2 |
DOIs | |
State | Published - 2004 |
Event | 2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada Duration: Aug 23 2004 → Aug 27 2004 |
Other
Other | 2004 IEEE Ultrasonics Symposium |
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Country | Canada |
City | Montreal, Que. |
Period | 8/23/04 → 8/27/04 |
ASJC Scopus subject areas
- Engineering(all)