Increasing binding efficiency of ultrasound targeted agents with radiation force

Shukui Zhao, Mark Borden, Susannah H. Bloch, Dustin E. Kruse, Katherine W. Ferrara, Paul A. Dayton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


We demonstrate both theoretically and experimentally that ultrasound radiation force can significantly increase the binding efficiency of targeted contrast agents, without increasing nonspecific adhesion of agents to the target surface. The radial oscillation of a microbubble was determined using a previously developed model, and then displacement and translational velocity were predicted by solving the trajectory equation of the microbubble. Theoretical evaluation showed that a microbubble can be easily displaced across a vessel by radiation force. Experiments with an avidin-coated tube and biotin-targeted microbubbles clearly demonstrated the effect of radiation force in increasing the efficiency of specific binding. Under control conditions, only sporadic binding to the vessel wall was observed. With radiation force, targeted agents adhered to the vessel wall at 20 times the rate of control experiments. An experiment with microbubbles targeted to α vβ 3expressing cells showed similar results.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
EditorsM.P. Yuhas
Number of pages4
StatePublished - 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: Aug 23 2004Aug 27 2004


Other2004 IEEE Ultrasonics Symposium
CityMontreal, Que.

ASJC Scopus subject areas

  • Engineering(all)


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