TY - JOUR
T1 - Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene- induced pulmonary injury
AU - Fanucchi, Michelle V.
AU - Day, Kimberly C.
AU - Clay, Candice C.
AU - Plopper, Charles
PY - 2004/11/15
Y1 - 2004/11/15
N2 - The postnatal period of lung development is a critical window of susceptibility to environmental toxicants, including polyaromatic hydrocarbons (PAHs) and furans. To determine whether the increased susceptibility of neonatal lung injury due to environmental toxicants is a universal response across species and also applies to nitrated compounds, adult and 7-day-old male mice and rats were given a single intraperitoneal dose (0, 12.5, 25, 50, or 100 mg/kg) of 1-nitronaphthalene and killed 24 h later. Exposure to 1-nitronaphthalene, a nitro-polyaromatic hydrocarbon, results in pulmonary lesions in both adult rats and mice, although the severity of the injury is species-specific (greater in rats than in mice). Pulmonary lesions, as assessed by quantitative histopathology, included dose-dependent vacuolization and exfoliation of both ciliated and nonciliated airway epithelial cells throughout the airway tree in both rats and mice. In both species, the 7-day-old animals were more susceptible to injury by 1-nitronaphthalene than adult animals. In contrast to adult response, neonatal mice were more susceptible to 1-nitronaphthalene-induced pulmonary injury than neonatal rats. This indicates that neonatal susceptibility to environmental pollutant-induced lung injury cannot be reliably predicted based on adult susceptibility.
AB - The postnatal period of lung development is a critical window of susceptibility to environmental toxicants, including polyaromatic hydrocarbons (PAHs) and furans. To determine whether the increased susceptibility of neonatal lung injury due to environmental toxicants is a universal response across species and also applies to nitrated compounds, adult and 7-day-old male mice and rats were given a single intraperitoneal dose (0, 12.5, 25, 50, or 100 mg/kg) of 1-nitronaphthalene and killed 24 h later. Exposure to 1-nitronaphthalene, a nitro-polyaromatic hydrocarbon, results in pulmonary lesions in both adult rats and mice, although the severity of the injury is species-specific (greater in rats than in mice). Pulmonary lesions, as assessed by quantitative histopathology, included dose-dependent vacuolization and exfoliation of both ciliated and nonciliated airway epithelial cells throughout the airway tree in both rats and mice. In both species, the 7-day-old animals were more susceptible to injury by 1-nitronaphthalene than adult animals. In contrast to adult response, neonatal mice were more susceptible to 1-nitronaphthalene-induced pulmonary injury than neonatal rats. This indicates that neonatal susceptibility to environmental pollutant-induced lung injury cannot be reliably predicted based on adult susceptibility.
KW - Environmental pollutants
KW - Polyaromatic hydrocarbons
KW - Postnatal lung susceptibility
UR - http://www.scopus.com/inward/record.url?scp=7444249128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7444249128&partnerID=8YFLogxK
U2 - 10.1016/j.taap.2004.05.002
DO - 10.1016/j.taap.2004.05.002
M3 - Article
C2 - 15519608
AN - SCOPUS:7444249128
VL - 201
SP - 53
EP - 65
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 1
ER -