Increased testicular Sertoli cell population induced by an estrogen receptor antagonist

Trish Berger, Alan J Conley, Monica Van Klompenberg, Janet F. Roser, Russell C. Hovey

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Sertoli cell proliferation is prolonged in neonatal boars treated with the aromatase inhibitor letrozole, but porcine testicular aromatase synthesizes a potent, non-aromatizable androgen, 1-hydroxytestosterone, as well as estradiol. Therefore, experiments were conducted to determine whether the Sertoli cell proliferative response to letrozole is due to a loss of estrogen or a loss of androgen signaling. Littermate boars were treated with letrozole, the estrogen receptor blocker ICI 182,780, or vehicle, from 1. week of age and testes collected at 6.5. weeks. Sertoli cell number was increased 30% by letrozole or ICI 182,780 compared with vehicle. Neither treatment affected testosterone, gonadotropins or prolactin. We conclude that Sertoli cell proliferation in neonatal boars is restricted by the local activation of estrogen receptors. The response to letrozole is apparently not mediated by the novel capacity of the porcine gonadal aromatase for 1-hydroxytestosterone but by estradiol synthesis; therefore, aromatase inhibition may have similar effects on Sertoli cell proliferation in other species.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume366
Issue number1
DOIs
StatePublished - Feb 5 2013

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Keywords

  • Endogenous estrogen
  • Proliferation
  • Sertoli cell
  • Testis development

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

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